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β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage
BACKGROUND: Cerebral Amyloid Angiopathy has been indicated as an important cause of spontaneous non-hypertensive intracerebral haemorrhage (ICH). AIMS: to analyze the presence of β-amyloid deposit in the temporal artery of consecutive patients with ICH in comparison to control subjects and its relat...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205179/ https://www.ncbi.nlm.nih.gov/pubmed/30410670 http://dx.doi.org/10.18632/oncotarget.26165 |
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author | Tuttolomondo, Antonino Maugeri, Rosario Orlando, Elisabetta Giannone, Giulio Ciccia, Francesco Rizzo, Aroldo Di Raimondo, Domenico Graziano, Francesca Pecoraro, Rosaria Maida, Carlo Simonetta, Irene Cirrincione, Anna Portelli, Francesca Corpora, Francesca Iacopino, Domenico Gerardo Pinto, Antonio |
author_facet | Tuttolomondo, Antonino Maugeri, Rosario Orlando, Elisabetta Giannone, Giulio Ciccia, Francesco Rizzo, Aroldo Di Raimondo, Domenico Graziano, Francesca Pecoraro, Rosaria Maida, Carlo Simonetta, Irene Cirrincione, Anna Portelli, Francesca Corpora, Francesca Iacopino, Domenico Gerardo Pinto, Antonio |
author_sort | Tuttolomondo, Antonino |
collection | PubMed |
description | BACKGROUND: Cerebral Amyloid Angiopathy has been indicated as an important cause of spontaneous non-hypertensive intracerebral haemorrhage (ICH). AIMS: to analyze the presence of β-amyloid deposit in the temporal artery of consecutive patients with ICH in comparison to control subjects and its relation to APO-E haplotype frequency. METHODS: We enrolled consecutive patients admitted to Neurosurgery Ward of University Hospital “P. Giaccone” of Palermo with a diagnosis of spontaneous non hypertensive ICH and as control 12 subjects without brain haemorrhage. Biopsy of superficial temporal artery has been performed and β-amyloid deposit was quantified. RESULTS: Among 25 subjects with ICH, 10 (40%) had APOE epsilon 2 allele and among these subjects 7 (70%) showed amyloid accumulation on temporal artery specimens, 8 (32%) subjects had APOE epsilon 3 allele and among these subjects only 2 (25%) showed amyloid accumulation on temporal artery specimens, whereas 7 (28%) had APOE epsilon 4 allele and of these, 7 (100%) showed amyloid accumulation on temporal artery specimens. At multivariable logistic regression analysis for the presence of amyloid, predictive factors for the presence of amyloid in temporal artery biopsies were: age, hypertension, intralobar site of haemorrhage, APOE epsilon 2 and APOE epsilon 4 alleles. DISCUSSION: Our findings of a higher frequency of amyloid deposition in temporal artery specimens in subjects with spontaneous intracerebral haemorrhage indicate a possible role of temporal artery as a possible diagnostic site of biopsy in subjects at high risk to develop intracranial haemorrhage related to Cerebral Amyloid Angiopathy. |
format | Online Article Text |
id | pubmed-6205179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-62051792018-11-08 β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage Tuttolomondo, Antonino Maugeri, Rosario Orlando, Elisabetta Giannone, Giulio Ciccia, Francesco Rizzo, Aroldo Di Raimondo, Domenico Graziano, Francesca Pecoraro, Rosaria Maida, Carlo Simonetta, Irene Cirrincione, Anna Portelli, Francesca Corpora, Francesca Iacopino, Domenico Gerardo Pinto, Antonio Oncotarget Research Paper BACKGROUND: Cerebral Amyloid Angiopathy has been indicated as an important cause of spontaneous non-hypertensive intracerebral haemorrhage (ICH). AIMS: to analyze the presence of β-amyloid deposit in the temporal artery of consecutive patients with ICH in comparison to control subjects and its relation to APO-E haplotype frequency. METHODS: We enrolled consecutive patients admitted to Neurosurgery Ward of University Hospital “P. Giaccone” of Palermo with a diagnosis of spontaneous non hypertensive ICH and as control 12 subjects without brain haemorrhage. Biopsy of superficial temporal artery has been performed and β-amyloid deposit was quantified. RESULTS: Among 25 subjects with ICH, 10 (40%) had APOE epsilon 2 allele and among these subjects 7 (70%) showed amyloid accumulation on temporal artery specimens, 8 (32%) subjects had APOE epsilon 3 allele and among these subjects only 2 (25%) showed amyloid accumulation on temporal artery specimens, whereas 7 (28%) had APOE epsilon 4 allele and of these, 7 (100%) showed amyloid accumulation on temporal artery specimens. At multivariable logistic regression analysis for the presence of amyloid, predictive factors for the presence of amyloid in temporal artery biopsies were: age, hypertension, intralobar site of haemorrhage, APOE epsilon 2 and APOE epsilon 4 alleles. DISCUSSION: Our findings of a higher frequency of amyloid deposition in temporal artery specimens in subjects with spontaneous intracerebral haemorrhage indicate a possible role of temporal artery as a possible diagnostic site of biopsy in subjects at high risk to develop intracranial haemorrhage related to Cerebral Amyloid Angiopathy. Impact Journals LLC 2018-10-05 /pmc/articles/PMC6205179/ /pubmed/30410670 http://dx.doi.org/10.18632/oncotarget.26165 Text en Copyright: © 2018 Tuttolomondo et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Tuttolomondo, Antonino Maugeri, Rosario Orlando, Elisabetta Giannone, Giulio Ciccia, Francesco Rizzo, Aroldo Di Raimondo, Domenico Graziano, Francesca Pecoraro, Rosaria Maida, Carlo Simonetta, Irene Cirrincione, Anna Portelli, Francesca Corpora, Francesca Iacopino, Domenico Gerardo Pinto, Antonio β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage |
title | β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage |
title_full | β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage |
title_fullStr | β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage |
title_full_unstemmed | β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage |
title_short | β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage |
title_sort | β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205179/ https://www.ncbi.nlm.nih.gov/pubmed/30410670 http://dx.doi.org/10.18632/oncotarget.26165 |
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