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Modelling ponatinib resistance in tyrosine kinase inhibitor-naïve and dasatinib resistant BCR-ABL1+ cell lines

TKI resistance remains a major impediment to successful treatment of CML. In this study, we investigated the emerging modes of ponatinib resistance in TKI-naïve and dasatinib resistant BCR-ABL1+ cell lines. To investigate potential resistance mechanisms, ponatinib resistance was generated in BCR-ABL...

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Detalles Bibliográficos
Autores principales:	Lu, Liu, Kok, Chung Hoow, Saunders, Verity Ann, Wang, Jueqiong, McLean, Jennifer Anne, Hughes, Timothy Peter, White, Deborah Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205183/ https://www.ncbi.nlm.nih.gov/pubmed/30410673 http://dx.doi.org/10.18632/oncotarget.26187

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