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Simultaneous Transepithelial Topography-Guided Photorefractive Keratectomy and Accelerated Cross-Linking in Keratoconus: 2-Year Follow-Up

PURPOSE: To evaluate the visual, refractive, and topographic outcomes after simultaneous topography-guided transepithelial photorefractive keratectomy (transepithelial TG-PRK) using the Amaris Excimer laser platform and accelerated corneal cross-linking (CXL) in eyes with keratoconus. MATERIALS AND...

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Autores principales: Ahmet, Sibel, Ağca, Alper, Yaşa, Dilek, Koç, Ahmet Alperen, Toğaç, Mesut, Yıldırım, Yusuf, Yıldız, Burçin Kepez, Demirok, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205309/
https://www.ncbi.nlm.nih.gov/pubmed/30410923
http://dx.doi.org/10.1155/2018/2945751
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author Ahmet, Sibel
Ağca, Alper
Yaşa, Dilek
Koç, Ahmet Alperen
Toğaç, Mesut
Yıldırım, Yusuf
Yıldız, Burçin Kepez
Demirok, Ahmet
author_facet Ahmet, Sibel
Ağca, Alper
Yaşa, Dilek
Koç, Ahmet Alperen
Toğaç, Mesut
Yıldırım, Yusuf
Yıldız, Burçin Kepez
Demirok, Ahmet
author_sort Ahmet, Sibel
collection PubMed
description PURPOSE: To evaluate the visual, refractive, and topographic outcomes after simultaneous topography-guided transepithelial photorefractive keratectomy (transepithelial TG-PRK) using the Amaris Excimer laser platform and accelerated corneal cross-linking (CXL) in eyes with keratoconus. MATERIALS AND METHODS: Patients with 2 years of follow-up were included in this retrospective case series. Manifest refraction (MR), uncorrected (UDVA) and corrected (CDVA) distance visual acuity, corneal topography, and pachymetry were evaluated at 1, 3, 6, 12, and 24 months after surgery. The root-mean-square of total higher-order aberrations (total HOA-RMS), coma (Coma-RMS), and spherical aberration (SA-RMS) were calculated for 4- and 6-mm diameters. RESULTS: Forty-six eyes of 46 patients were included in the study. Stromal ablation was ≤50 μ in all patients. MR was −3.78±3.26 preoperatively and −1.39±1.82 postoperatively. Significant improvements were seen in the UDVA and Coma-RMS values at 1 month, CDVA and total HOA-RMS values at 3 months, and SA-RMS values at 1 year compared to preoperative levels. UDVA values further improved after 2 years, compared to the 1-year values. No patient lost two or more lines and keratoconus progression was not observed in any patient. CONCLUSION: Simultaneous transepithelial TG-PRK and accelerated CXL resulted in significant gains in CDVA without compromising CXL efficacy.
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spelling pubmed-62053092018-11-08 Simultaneous Transepithelial Topography-Guided Photorefractive Keratectomy and Accelerated Cross-Linking in Keratoconus: 2-Year Follow-Up Ahmet, Sibel Ağca, Alper Yaşa, Dilek Koç, Ahmet Alperen Toğaç, Mesut Yıldırım, Yusuf Yıldız, Burçin Kepez Demirok, Ahmet Biomed Res Int Clinical Study PURPOSE: To evaluate the visual, refractive, and topographic outcomes after simultaneous topography-guided transepithelial photorefractive keratectomy (transepithelial TG-PRK) using the Amaris Excimer laser platform and accelerated corneal cross-linking (CXL) in eyes with keratoconus. MATERIALS AND METHODS: Patients with 2 years of follow-up were included in this retrospective case series. Manifest refraction (MR), uncorrected (UDVA) and corrected (CDVA) distance visual acuity, corneal topography, and pachymetry were evaluated at 1, 3, 6, 12, and 24 months after surgery. The root-mean-square of total higher-order aberrations (total HOA-RMS), coma (Coma-RMS), and spherical aberration (SA-RMS) were calculated for 4- and 6-mm diameters. RESULTS: Forty-six eyes of 46 patients were included in the study. Stromal ablation was ≤50 μ in all patients. MR was −3.78±3.26 preoperatively and −1.39±1.82 postoperatively. Significant improvements were seen in the UDVA and Coma-RMS values at 1 month, CDVA and total HOA-RMS values at 3 months, and SA-RMS values at 1 year compared to preoperative levels. UDVA values further improved after 2 years, compared to the 1-year values. No patient lost two or more lines and keratoconus progression was not observed in any patient. CONCLUSION: Simultaneous transepithelial TG-PRK and accelerated CXL resulted in significant gains in CDVA without compromising CXL efficacy. Hindawi 2018-10-15 /pmc/articles/PMC6205309/ /pubmed/30410923 http://dx.doi.org/10.1155/2018/2945751 Text en Copyright © 2018 Sibel Ahmet et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Ahmet, Sibel
Ağca, Alper
Yaşa, Dilek
Koç, Ahmet Alperen
Toğaç, Mesut
Yıldırım, Yusuf
Yıldız, Burçin Kepez
Demirok, Ahmet
Simultaneous Transepithelial Topography-Guided Photorefractive Keratectomy and Accelerated Cross-Linking in Keratoconus: 2-Year Follow-Up
title Simultaneous Transepithelial Topography-Guided Photorefractive Keratectomy and Accelerated Cross-Linking in Keratoconus: 2-Year Follow-Up
title_full Simultaneous Transepithelial Topography-Guided Photorefractive Keratectomy and Accelerated Cross-Linking in Keratoconus: 2-Year Follow-Up
title_fullStr Simultaneous Transepithelial Topography-Guided Photorefractive Keratectomy and Accelerated Cross-Linking in Keratoconus: 2-Year Follow-Up
title_full_unstemmed Simultaneous Transepithelial Topography-Guided Photorefractive Keratectomy and Accelerated Cross-Linking in Keratoconus: 2-Year Follow-Up
title_short Simultaneous Transepithelial Topography-Guided Photorefractive Keratectomy and Accelerated Cross-Linking in Keratoconus: 2-Year Follow-Up
title_sort simultaneous transepithelial topography-guided photorefractive keratectomy and accelerated cross-linking in keratoconus: 2-year follow-up
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205309/
https://www.ncbi.nlm.nih.gov/pubmed/30410923
http://dx.doi.org/10.1155/2018/2945751
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