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Genetic Strategies for HIV Treatment and Prevention
Conventional HIV gene therapy approaches are based on engineering HIV target cells that are non-permissive to viral replication. However, expansion of gene-modified HIV target cells has been limited in patients. Alternative genetic strategies focus on generating gene-modified producer cells that sec...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205348/ https://www.ncbi.nlm.nih.gov/pubmed/30388625 http://dx.doi.org/10.1016/j.omtn.2018.09.018 |
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author | Falkenhagen, Alexander Joshi, Sadhna |
author_facet | Falkenhagen, Alexander Joshi, Sadhna |
author_sort | Falkenhagen, Alexander |
collection | PubMed |
description | Conventional HIV gene therapy approaches are based on engineering HIV target cells that are non-permissive to viral replication. However, expansion of gene-modified HIV target cells has been limited in patients. Alternative genetic strategies focus on generating gene-modified producer cells that secrete antiviral proteins (AVPs). The secreted AVPs interfere with HIV entry, and, therefore, they extend the protection against infection to unmodified HIV target cells. Since any cell type can potentially secrete AVPs, hematopoietic and non-hematopoietic cell lineages can function as producer cells. Secretion of AVPs from non-hematopoietic cells opens the possibility of using a genetic approach for HIV prevention. Another strategy aims at modifying cytotoxic T cells to selectively target and eliminate infected cells. This review provides an overview of the different genetic approaches for HIV treatment and prevention. |
format | Online Article Text |
id | pubmed-6205348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Society of Gene & Cell Therapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-62053482018-11-05 Genetic Strategies for HIV Treatment and Prevention Falkenhagen, Alexander Joshi, Sadhna Mol Ther Nucleic Acids Article Conventional HIV gene therapy approaches are based on engineering HIV target cells that are non-permissive to viral replication. However, expansion of gene-modified HIV target cells has been limited in patients. Alternative genetic strategies focus on generating gene-modified producer cells that secrete antiviral proteins (AVPs). The secreted AVPs interfere with HIV entry, and, therefore, they extend the protection against infection to unmodified HIV target cells. Since any cell type can potentially secrete AVPs, hematopoietic and non-hematopoietic cell lineages can function as producer cells. Secretion of AVPs from non-hematopoietic cells opens the possibility of using a genetic approach for HIV prevention. Another strategy aims at modifying cytotoxic T cells to selectively target and eliminate infected cells. This review provides an overview of the different genetic approaches for HIV treatment and prevention. American Society of Gene & Cell Therapy 2018-09-29 /pmc/articles/PMC6205348/ /pubmed/30388625 http://dx.doi.org/10.1016/j.omtn.2018.09.018 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Falkenhagen, Alexander Joshi, Sadhna Genetic Strategies for HIV Treatment and Prevention |
title | Genetic Strategies for HIV Treatment and Prevention |
title_full | Genetic Strategies for HIV Treatment and Prevention |
title_fullStr | Genetic Strategies for HIV Treatment and Prevention |
title_full_unstemmed | Genetic Strategies for HIV Treatment and Prevention |
title_short | Genetic Strategies for HIV Treatment and Prevention |
title_sort | genetic strategies for hiv treatment and prevention |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205348/ https://www.ncbi.nlm.nih.gov/pubmed/30388625 http://dx.doi.org/10.1016/j.omtn.2018.09.018 |
work_keys_str_mv | AT falkenhagenalexander geneticstrategiesforhivtreatmentandprevention AT joshisadhna geneticstrategiesforhivtreatmentandprevention |