Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism

Damage to intestinal epithelial cell (IEC) layers during intestinal inflammation is associated with inflammatory bowel disease. Here we show that the endoribonuclease Regnase-1 controls colon epithelial regeneration by regulating protein kinase mTOR (the mechanistic target of rapamycin kinase) and p...

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Detalles Bibliográficos
Autores principales: Nagahama, Yasuharu, Shimoda, Mayuko, Mao, Guoliang, Singh, Shailendra Kumar, Kozakai, Yuuki, Sun, Xin, Motooka, Daisuke, Nakamura, Shota, Tanaka, Hiroki, Satoh, Takashi, Maeda, Kazuhiko, Akira, Shizuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205455/
https://www.ncbi.nlm.nih.gov/pubmed/30297433
http://dx.doi.org/10.1073/pnas.1809575115

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