CYP2D6 genotype can help to predict effectiveness and safety during opioid treatment for chronic low back pain: results from a retrospective study in an Italian cohort

BACKGROUND: Opioids are widely used for chronic low back pain (CLBP); however, it is still unclear how to predict their effectiveness and safety. Codeine, tramadol and oxycodone are metabolized by CYP/CYP450 2D6 (CYP2D6), a highly polymorphic enzyme linked to allele-specific related differences in m...

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Detalles Bibliográficos
Autores principales: Dagostino, Concetta, Allegri, Massimo, Napolioni, Valerio, D’Agnelli, Simona, Bignami, Elena, Mutti, Antonio, van Schaik, Ron HN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205525/
https://www.ncbi.nlm.nih.gov/pubmed/30425549
http://dx.doi.org/10.2147/PGPM.S181334

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