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A distinct strain of Arsenophonus symbiont decreases insecticide resistance in its insect host

Symbiotic bacteria are important drivers of phenotypic diversity in insects. One of the widespread symbionts to have emerged belongs to the genus Arsenophonus, however, its biological functions in most host insects remain entirely unknown. Here we report two distinct Arsenophonus strains in the brow...

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Autores principales: Pang, Rui, Chen, Meng, Yue, Lei, Xing, Ke, Li, Tengchao, Kang, Kui, Liang, Zhikun, Yuan, Longyu, Zhang, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205657/
https://www.ncbi.nlm.nih.gov/pubmed/30332402
http://dx.doi.org/10.1371/journal.pgen.1007725
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author Pang, Rui
Chen, Meng
Yue, Lei
Xing, Ke
Li, Tengchao
Kang, Kui
Liang, Zhikun
Yuan, Longyu
Zhang, Wenqing
author_facet Pang, Rui
Chen, Meng
Yue, Lei
Xing, Ke
Li, Tengchao
Kang, Kui
Liang, Zhikun
Yuan, Longyu
Zhang, Wenqing
author_sort Pang, Rui
collection PubMed
description Symbiotic bacteria are important drivers of phenotypic diversity in insects. One of the widespread symbionts to have emerged belongs to the genus Arsenophonus, however, its biological functions in most host insects remain entirely unknown. Here we report two distinct Arsenophonus strains in the brown planthopper (BPH), Nilaparvata lugens, a major pest insect in Asian countries that causes significant economic damage through rice crop destruction. Genomic resequencing data suggested that one Arsenophonus strain (S-type) negatively affected the insecticide resistance of the host. Indeed, replacement of the resident Arsenophonus with the S-type Arsenophonus significantly decreased host insecticide resistance. Transcriptome and metabolome analysis revealed down-regulation of xenobiotic metabolism and increased amino acid accumulation in the S-type Arsenophonus infected host. This study demonstrates how a symbiont-mediated phenotypic change can occur. The results of this study will aid in developing strategies that work through imposing an ecological disadvantage on insect pests, which will be of great value for pest control in agricultural industry.
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spelling pubmed-62056572018-11-19 A distinct strain of Arsenophonus symbiont decreases insecticide resistance in its insect host Pang, Rui Chen, Meng Yue, Lei Xing, Ke Li, Tengchao Kang, Kui Liang, Zhikun Yuan, Longyu Zhang, Wenqing PLoS Genet Research Article Symbiotic bacteria are important drivers of phenotypic diversity in insects. One of the widespread symbionts to have emerged belongs to the genus Arsenophonus, however, its biological functions in most host insects remain entirely unknown. Here we report two distinct Arsenophonus strains in the brown planthopper (BPH), Nilaparvata lugens, a major pest insect in Asian countries that causes significant economic damage through rice crop destruction. Genomic resequencing data suggested that one Arsenophonus strain (S-type) negatively affected the insecticide resistance of the host. Indeed, replacement of the resident Arsenophonus with the S-type Arsenophonus significantly decreased host insecticide resistance. Transcriptome and metabolome analysis revealed down-regulation of xenobiotic metabolism and increased amino acid accumulation in the S-type Arsenophonus infected host. This study demonstrates how a symbiont-mediated phenotypic change can occur. The results of this study will aid in developing strategies that work through imposing an ecological disadvantage on insect pests, which will be of great value for pest control in agricultural industry. Public Library of Science 2018-10-17 /pmc/articles/PMC6205657/ /pubmed/30332402 http://dx.doi.org/10.1371/journal.pgen.1007725 Text en © 2018 Pang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pang, Rui
Chen, Meng
Yue, Lei
Xing, Ke
Li, Tengchao
Kang, Kui
Liang, Zhikun
Yuan, Longyu
Zhang, Wenqing
A distinct strain of Arsenophonus symbiont decreases insecticide resistance in its insect host
title A distinct strain of Arsenophonus symbiont decreases insecticide resistance in its insect host
title_full A distinct strain of Arsenophonus symbiont decreases insecticide resistance in its insect host
title_fullStr A distinct strain of Arsenophonus symbiont decreases insecticide resistance in its insect host
title_full_unstemmed A distinct strain of Arsenophonus symbiont decreases insecticide resistance in its insect host
title_short A distinct strain of Arsenophonus symbiont decreases insecticide resistance in its insect host
title_sort distinct strain of arsenophonus symbiont decreases insecticide resistance in its insect host
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205657/
https://www.ncbi.nlm.nih.gov/pubmed/30332402
http://dx.doi.org/10.1371/journal.pgen.1007725
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