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Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity
Centrosomes serve as the major microtubule organizing centers in cells and thereby contribute to cell shape, polarity, and motility. Also, centrosomes ensure equal chromosome segregation during mitosis. Centrosome aberrations arise when the centrosome cycle is deregulated, or as a result of cytokine...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205736/ https://www.ncbi.nlm.nih.gov/pubmed/30381801 http://dx.doi.org/10.20517/2394-4722.2018.24 |