TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma

PURPOSE: Elevations in intraocular pressure (IOP) are associated with the development of glaucoma and loss of sight. High transforming growth factor-β (TGF-β) 1 levels in the eye’s anterior chamber can lead to dysfunctional contractions through RhoA signaling in trabecular meshwork (TM) cells and IO...

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Detalles Bibliográficos
Autores principales: Hill, Lisa J., Mead, Ben, Thomas, Chloe N, Foale, Simon, Feinstein, Elena, Berry, Martin, Blanch, Richard J., Ahmed, Zubair, Logan, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205807/
https://www.ncbi.nlm.nih.gov/pubmed/30429640

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