The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α

Deviating from the normal karyotype dramatically changes gene dosage, in turn decreasing the robustness of biological networks. Consequently, aneuploidy is poorly tolerated by normal somatic cells and acts as a barrier to transformation. Paradoxically, however, karyotype heterogeneity drives tumor e...

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Detalles Bibliográficos
Autores principales: Simões-Sousa, Susana, Littler, Samantha, Thompson, Sarah L., Minshall, Paul, Whalley, Helen, Bakker, Bjorn, Belkot, Klaudyna, Moralli, Daniela, Bronder, Daniel, Tighe, Anthony, Spierings, Diana C.J., Bah, Nourdine, Graham, Joshua, Nelson, Louisa, Green, Catherine M., Foijer, Floris, Townsend, Paul A., Taylor, Stephen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205844/
https://www.ncbi.nlm.nih.gov/pubmed/30332653
http://dx.doi.org/10.1016/j.celrep.2018.09.060

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