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Fetal/Neonatal Pericardial Effusion in Down's Syndrome: Case Report and Review of Literature

We report a preterm (35 (4/7) weeks) male neonate with Down's syndrome (DS) diagnosed with isolated pericardial effusion (PE) at 20 weeks of gestation. He was born by precipitous delivery, needed no resuscitation and presented within first 24 hours of life with respiratory distress, anemia due...

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Autores principales: Pharande, Pramod, Balegar Virupakshappa, Kiran Kumar, Mehta, Bhavesh, Badawi, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical Publishers 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205858/
https://www.ncbi.nlm.nih.gov/pubmed/30377554
http://dx.doi.org/10.1055/s-0038-1675337
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author Pharande, Pramod
Balegar Virupakshappa, Kiran Kumar
Mehta, Bhavesh
Badawi, Nadia
author_facet Pharande, Pramod
Balegar Virupakshappa, Kiran Kumar
Mehta, Bhavesh
Badawi, Nadia
author_sort Pharande, Pramod
collection PubMed
description We report a preterm (35 (4/7) weeks) male neonate with Down's syndrome (DS) diagnosed with isolated pericardial effusion (PE) at 20 weeks of gestation. He was born by precipitous delivery, needed no resuscitation and presented within first 24 hours of life with respiratory distress, anemia due to feto-maternal bleed, hypotension, hepatomegaly, and coagulopathy. Postnatal echocardiography confirmed a 5 mm rim of PE without tamponade, normal cardiac structure, and function. He was stabilized with ventilation, packed red cell, fresh frozen plasma, inotropes (dopamine, dobutamine, and adrenaline), and steroid (hydrocortisone). Subsequent evaluation confirmed hypothyroidism, transient myeloproliferative disorder (TMD), hepatic failure due to fibrosis/cirrhosis with portal hypertension, and steroid sensitive hypotension on two occasions possibly due to adrenal insufficiency. PE completely resolved over 2 weeks. In view of progressively worsening liver failure with ascites and portal hypertension, the family opted for palliation. Literature review has been discussed regarding perinatal onset of PE in DS.
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spelling pubmed-62058582018-10-30 Fetal/Neonatal Pericardial Effusion in Down's Syndrome: Case Report and Review of Literature Pharande, Pramod Balegar Virupakshappa, Kiran Kumar Mehta, Bhavesh Badawi, Nadia AJP Rep We report a preterm (35 (4/7) weeks) male neonate with Down's syndrome (DS) diagnosed with isolated pericardial effusion (PE) at 20 weeks of gestation. He was born by precipitous delivery, needed no resuscitation and presented within first 24 hours of life with respiratory distress, anemia due to feto-maternal bleed, hypotension, hepatomegaly, and coagulopathy. Postnatal echocardiography confirmed a 5 mm rim of PE without tamponade, normal cardiac structure, and function. He was stabilized with ventilation, packed red cell, fresh frozen plasma, inotropes (dopamine, dobutamine, and adrenaline), and steroid (hydrocortisone). Subsequent evaluation confirmed hypothyroidism, transient myeloproliferative disorder (TMD), hepatic failure due to fibrosis/cirrhosis with portal hypertension, and steroid sensitive hypotension on two occasions possibly due to adrenal insufficiency. PE completely resolved over 2 weeks. In view of progressively worsening liver failure with ascites and portal hypertension, the family opted for palliation. Literature review has been discussed regarding perinatal onset of PE in DS. Thieme Medical Publishers 2018-10 2018-10-29 /pmc/articles/PMC6205858/ /pubmed/30377554 http://dx.doi.org/10.1055/s-0038-1675337 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Pharande, Pramod
Balegar Virupakshappa, Kiran Kumar
Mehta, Bhavesh
Badawi, Nadia
Fetal/Neonatal Pericardial Effusion in Down's Syndrome: Case Report and Review of Literature
title Fetal/Neonatal Pericardial Effusion in Down's Syndrome: Case Report and Review of Literature
title_full Fetal/Neonatal Pericardial Effusion in Down's Syndrome: Case Report and Review of Literature
title_fullStr Fetal/Neonatal Pericardial Effusion in Down's Syndrome: Case Report and Review of Literature
title_full_unstemmed Fetal/Neonatal Pericardial Effusion in Down's Syndrome: Case Report and Review of Literature
title_short Fetal/Neonatal Pericardial Effusion in Down's Syndrome: Case Report and Review of Literature
title_sort fetal/neonatal pericardial effusion in down's syndrome: case report and review of literature
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205858/
https://www.ncbi.nlm.nih.gov/pubmed/30377554
http://dx.doi.org/10.1055/s-0038-1675337
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