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Regulation of FGF10 Signaling in Development and Disease
Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling growth factor, which is essential for multi-organ development and tissue homeostasis in adults. Furthermore, FGF10 deregulation has been associated with human genetic disorders and certain forms of cancer. Upon...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205963/ https://www.ncbi.nlm.nih.gov/pubmed/30405705 http://dx.doi.org/10.3389/fgene.2018.00500 |
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author | Watson, Joanne Francavilla, Chiara |
author_facet | Watson, Joanne Francavilla, Chiara |
author_sort | Watson, Joanne |
collection | PubMed |
description | Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling growth factor, which is essential for multi-organ development and tissue homeostasis in adults. Furthermore, FGF10 deregulation has been associated with human genetic disorders and certain forms of cancer. Upon binding to FGF receptors with heparan sulfate as co-factor, FGF10 activates several intracellular signaling cascades, resulting in cell proliferation, differentiation, and invasion. FGF10 activity is modulated not only by heparan sulfate proteoglycans in the extracellular matrix, but also by hormones and other soluble factors. Despite more than 20 years of research on FGF10 functions, context-dependent regulation of FGF10 signaling specificity remains poorly understood. Emerging modes of FGF10 signaling regulation will be described, focusing on the role of FGF10 trafficking and sub-cellular localization, heparan sulfate proteoglycans, and miRNAs. Systems biology approaches based on quantitative proteomics will be considered for globally investigating FGF10 signaling specificity. Finally, current gaps in our understanding of FGF10 functions, such as the relative contribution of receptor isoforms to signaling activation, will be discussed in the context of genetic disorders and tumorigenesis. |
format | Online Article Text |
id | pubmed-6205963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62059632018-11-07 Regulation of FGF10 Signaling in Development and Disease Watson, Joanne Francavilla, Chiara Front Genet Genetics Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling growth factor, which is essential for multi-organ development and tissue homeostasis in adults. Furthermore, FGF10 deregulation has been associated with human genetic disorders and certain forms of cancer. Upon binding to FGF receptors with heparan sulfate as co-factor, FGF10 activates several intracellular signaling cascades, resulting in cell proliferation, differentiation, and invasion. FGF10 activity is modulated not only by heparan sulfate proteoglycans in the extracellular matrix, but also by hormones and other soluble factors. Despite more than 20 years of research on FGF10 functions, context-dependent regulation of FGF10 signaling specificity remains poorly understood. Emerging modes of FGF10 signaling regulation will be described, focusing on the role of FGF10 trafficking and sub-cellular localization, heparan sulfate proteoglycans, and miRNAs. Systems biology approaches based on quantitative proteomics will be considered for globally investigating FGF10 signaling specificity. Finally, current gaps in our understanding of FGF10 functions, such as the relative contribution of receptor isoforms to signaling activation, will be discussed in the context of genetic disorders and tumorigenesis. Frontiers Media S.A. 2018-10-23 /pmc/articles/PMC6205963/ /pubmed/30405705 http://dx.doi.org/10.3389/fgene.2018.00500 Text en Copyright © 2018 Watson and Francavilla. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Watson, Joanne Francavilla, Chiara Regulation of FGF10 Signaling in Development and Disease |
title | Regulation of FGF10 Signaling in Development and Disease |
title_full | Regulation of FGF10 Signaling in Development and Disease |
title_fullStr | Regulation of FGF10 Signaling in Development and Disease |
title_full_unstemmed | Regulation of FGF10 Signaling in Development and Disease |
title_short | Regulation of FGF10 Signaling in Development and Disease |
title_sort | regulation of fgf10 signaling in development and disease |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205963/ https://www.ncbi.nlm.nih.gov/pubmed/30405705 http://dx.doi.org/10.3389/fgene.2018.00500 |
work_keys_str_mv | AT watsonjoanne regulationoffgf10signalingindevelopmentanddisease AT francavillachiara regulationoffgf10signalingindevelopmentanddisease |