Cargando…

Regulation of FGF10 Signaling in Development and Disease

Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling growth factor, which is essential for multi-organ development and tissue homeostasis in adults. Furthermore, FGF10 deregulation has been associated with human genetic disorders and certain forms of cancer. Upon...

Descripción completa

Detalles Bibliográficos
Autores principales: Watson, Joanne, Francavilla, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205963/
https://www.ncbi.nlm.nih.gov/pubmed/30405705
http://dx.doi.org/10.3389/fgene.2018.00500
_version_ 1783366267664596992
author Watson, Joanne
Francavilla, Chiara
author_facet Watson, Joanne
Francavilla, Chiara
author_sort Watson, Joanne
collection PubMed
description Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling growth factor, which is essential for multi-organ development and tissue homeostasis in adults. Furthermore, FGF10 deregulation has been associated with human genetic disorders and certain forms of cancer. Upon binding to FGF receptors with heparan sulfate as co-factor, FGF10 activates several intracellular signaling cascades, resulting in cell proliferation, differentiation, and invasion. FGF10 activity is modulated not only by heparan sulfate proteoglycans in the extracellular matrix, but also by hormones and other soluble factors. Despite more than 20 years of research on FGF10 functions, context-dependent regulation of FGF10 signaling specificity remains poorly understood. Emerging modes of FGF10 signaling regulation will be described, focusing on the role of FGF10 trafficking and sub-cellular localization, heparan sulfate proteoglycans, and miRNAs. Systems biology approaches based on quantitative proteomics will be considered for globally investigating FGF10 signaling specificity. Finally, current gaps in our understanding of FGF10 functions, such as the relative contribution of receptor isoforms to signaling activation, will be discussed in the context of genetic disorders and tumorigenesis.
format Online
Article
Text
id pubmed-6205963
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-62059632018-11-07 Regulation of FGF10 Signaling in Development and Disease Watson, Joanne Francavilla, Chiara Front Genet Genetics Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling growth factor, which is essential for multi-organ development and tissue homeostasis in adults. Furthermore, FGF10 deregulation has been associated with human genetic disorders and certain forms of cancer. Upon binding to FGF receptors with heparan sulfate as co-factor, FGF10 activates several intracellular signaling cascades, resulting in cell proliferation, differentiation, and invasion. FGF10 activity is modulated not only by heparan sulfate proteoglycans in the extracellular matrix, but also by hormones and other soluble factors. Despite more than 20 years of research on FGF10 functions, context-dependent regulation of FGF10 signaling specificity remains poorly understood. Emerging modes of FGF10 signaling regulation will be described, focusing on the role of FGF10 trafficking and sub-cellular localization, heparan sulfate proteoglycans, and miRNAs. Systems biology approaches based on quantitative proteomics will be considered for globally investigating FGF10 signaling specificity. Finally, current gaps in our understanding of FGF10 functions, such as the relative contribution of receptor isoforms to signaling activation, will be discussed in the context of genetic disorders and tumorigenesis. Frontiers Media S.A. 2018-10-23 /pmc/articles/PMC6205963/ /pubmed/30405705 http://dx.doi.org/10.3389/fgene.2018.00500 Text en Copyright © 2018 Watson and Francavilla. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Watson, Joanne
Francavilla, Chiara
Regulation of FGF10 Signaling in Development and Disease
title Regulation of FGF10 Signaling in Development and Disease
title_full Regulation of FGF10 Signaling in Development and Disease
title_fullStr Regulation of FGF10 Signaling in Development and Disease
title_full_unstemmed Regulation of FGF10 Signaling in Development and Disease
title_short Regulation of FGF10 Signaling in Development and Disease
title_sort regulation of fgf10 signaling in development and disease
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205963/
https://www.ncbi.nlm.nih.gov/pubmed/30405705
http://dx.doi.org/10.3389/fgene.2018.00500
work_keys_str_mv AT watsonjoanne regulationoffgf10signalingindevelopmentanddisease
AT francavillachiara regulationoffgf10signalingindevelopmentanddisease