Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity

Ultraviolet (UV) light is an important environmental trigger for systemic lupus erythematosus (SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known. This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wolf, Sonya J., Estadt, Shannon N., Gudjonsson, Johann E., Kahlenberg, J. Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205973/
https://www.ncbi.nlm.nih.gov/pubmed/30405625
http://dx.doi.org/10.3389/fimmu.2018.02430
_version_ 1783366270216830976
author Wolf, Sonya J.
Estadt, Shannon N.
Gudjonsson, Johann E.
Kahlenberg, J. Michelle
author_facet Wolf, Sonya J.
Estadt, Shannon N.
Gudjonsson, Johann E.
Kahlenberg, J. Michelle
author_sort Wolf, Sonya J.
collection PubMed
description Ultraviolet (UV) light is an important environmental trigger for systemic lupus erythematosus (SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known. This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment, and systemic flare induction. In addition, the role of the circadian clock is discussed. Evidence is compared in healthy individuals and SLE patients as well as in wild-type and lupus-prone mice. Further research is needed into the effects of UV light on cutaneous and systemic immune responses to understand how to prevent UV-light mediated lupus flares.
format Online
Article
Text
id pubmed-6205973
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-62059732018-11-07 Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity Wolf, Sonya J. Estadt, Shannon N. Gudjonsson, Johann E. Kahlenberg, J. Michelle Front Immunol Immunology Ultraviolet (UV) light is an important environmental trigger for systemic lupus erythematosus (SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known. This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment, and systemic flare induction. In addition, the role of the circadian clock is discussed. Evidence is compared in healthy individuals and SLE patients as well as in wild-type and lupus-prone mice. Further research is needed into the effects of UV light on cutaneous and systemic immune responses to understand how to prevent UV-light mediated lupus flares. Frontiers Media S.A. 2018-10-23 /pmc/articles/PMC6205973/ /pubmed/30405625 http://dx.doi.org/10.3389/fimmu.2018.02430 Text en Copyright © 2018 Wolf, Estadt, Gudjonsson and Kahlenberg. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wolf, Sonya J.
Estadt, Shannon N.
Gudjonsson, Johann E.
Kahlenberg, J. Michelle
Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity
title Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity
title_full Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity
title_fullStr Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity
title_full_unstemmed Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity
title_short Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity
title_sort human and murine evidence for mechanisms driving autoimmune photosensitivity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205973/
https://www.ncbi.nlm.nih.gov/pubmed/30405625
http://dx.doi.org/10.3389/fimmu.2018.02430
work_keys_str_mv AT wolfsonyaj humanandmurineevidenceformechanismsdrivingautoimmunephotosensitivity
AT estadtshannonn humanandmurineevidenceformechanismsdrivingautoimmunephotosensitivity
AT gudjonssonjohanne humanandmurineevidenceformechanismsdrivingautoimmunephotosensitivity
AT kahlenbergjmichelle humanandmurineevidenceformechanismsdrivingautoimmunephotosensitivity

Ejemplares similares