Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

Complex I (proton-pumping NADH:ubiquinone oxidoreductase) is the largest enzyme of the mitochondrial respiratory chain and a significant source of reactive oxygen species (ROS). We hypothesized that during energy conversion by complex I, electron transfer onto ubiquinone triggers the concerted rearr...

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Detalles Bibliográficos
Autores principales: Cabrera-Orefice, Alfredo, Yoga, Etienne Galemou, Wirth, Christophe, Siegmund, Karin, Zwicker, Klaus, Guerrero-Castillo, Sergio, Zickermann, Volker, Hunte, Carola, Brandt, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206036/
https://www.ncbi.nlm.nih.gov/pubmed/30374105
http://dx.doi.org/10.1038/s41467-018-06955-y

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