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Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

Therapeutic alteration of gene expression in vivo can be achieved by delivering nucleic acids (e.g., mRNA, siRNA) using nanoparticles. Recent progress in modified messenger RNA (mmRNA) synthesis facilitated the development of lipid nanoparticles (LNPs) loaded with mmRNA as a promising tool for in vi...

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Detalles Bibliográficos
Autores principales:	Veiga, Nuphar, Goldsmith, Meir, Granot, Yasmin, Rosenblum, Daniel, Dammes, Niels, Kedmi, Ranit, Ramishetti, Srinivas, Peer, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206083/ https://www.ncbi.nlm.nih.gov/pubmed/30374059 http://dx.doi.org/10.1038/s41467-018-06936-1

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