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Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population

Prediabetic subjects represent a vulnerable population, requiring special care to reduce the risk of diabetes onset. We developed and validated a diabetes risk score for prediabetic subjects using the Korea National Diabetes Program (KNDP) cohort. Subjects included in the multicenter and prospective...

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Autores principales: Ustulin, Morena, Rhee, Sang Youl, Chon, Suk, Ahn, Kyu Keung, Lim, Ji Eun, Oh, Bermseok, Kim, Sung-Hoon, Baik, Sei Hyun, Park, Yongsoo, Nam, Moon Suk, Lee, Kwan Woo, Kim, Young Seol, Woo, Jeong-Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206127/
https://www.ncbi.nlm.nih.gov/pubmed/30374195
http://dx.doi.org/10.1038/s41598-018-34411-w
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author Ustulin, Morena
Rhee, Sang Youl
Chon, Suk
Ahn, Kyu Keung
Lim, Ji Eun
Oh, Bermseok
Kim, Sung-Hoon
Baik, Sei Hyun
Park, Yongsoo
Nam, Moon Suk
Lee, Kwan Woo
Kim, Young Seol
Woo, Jeong-Taek
author_facet Ustulin, Morena
Rhee, Sang Youl
Chon, Suk
Ahn, Kyu Keung
Lim, Ji Eun
Oh, Bermseok
Kim, Sung-Hoon
Baik, Sei Hyun
Park, Yongsoo
Nam, Moon Suk
Lee, Kwan Woo
Kim, Young Seol
Woo, Jeong-Taek
author_sort Ustulin, Morena
collection PubMed
description Prediabetic subjects represent a vulnerable population, requiring special care to reduce the risk of diabetes onset. We developed and validated a diabetes risk score for prediabetic subjects using the Korea National Diabetes Program (KNDP) cohort. Subjects included in the multicenter and prospective cohort (n = 1162) had high diabetes risk at baseline (2005) and were followed until 2012. Survival analysis was performed to analyze the prospective cohort over time, and the bootstrap method was used to validate our model. We confirmed our findings in an external cohort. A diabetes risk score was calculated and the cut-off defined using a receiver operating characteristic curve. Age, body mass index, total cholesterol, and family history of diabetes were associated with diabetes. The model performed well after correction for optimism (C(adj) = 0.735). A risk score was defined with a cut-off of ≥5 that maximized sensitivity (72%) and specificity (62%), with an area under the curve of 0.73. Prediabetic subjects with a family history of diabetes had a higher probability of diabetes (risk score = 5) irrespective of other variables; this result was confirmed in the external cohort. Hence, prediabetic subjects with a family history of diabetes have a higher probability of developing diabetes, regardless of other clinical factors.
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spelling pubmed-62061272018-11-01 Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population Ustulin, Morena Rhee, Sang Youl Chon, Suk Ahn, Kyu Keung Lim, Ji Eun Oh, Bermseok Kim, Sung-Hoon Baik, Sei Hyun Park, Yongsoo Nam, Moon Suk Lee, Kwan Woo Kim, Young Seol Woo, Jeong-Taek Sci Rep Article Prediabetic subjects represent a vulnerable population, requiring special care to reduce the risk of diabetes onset. We developed and validated a diabetes risk score for prediabetic subjects using the Korea National Diabetes Program (KNDP) cohort. Subjects included in the multicenter and prospective cohort (n = 1162) had high diabetes risk at baseline (2005) and were followed until 2012. Survival analysis was performed to analyze the prospective cohort over time, and the bootstrap method was used to validate our model. We confirmed our findings in an external cohort. A diabetes risk score was calculated and the cut-off defined using a receiver operating characteristic curve. Age, body mass index, total cholesterol, and family history of diabetes were associated with diabetes. The model performed well after correction for optimism (C(adj) = 0.735). A risk score was defined with a cut-off of ≥5 that maximized sensitivity (72%) and specificity (62%), with an area under the curve of 0.73. Prediabetic subjects with a family history of diabetes had a higher probability of diabetes (risk score = 5) irrespective of other variables; this result was confirmed in the external cohort. Hence, prediabetic subjects with a family history of diabetes have a higher probability of developing diabetes, regardless of other clinical factors. Nature Publishing Group UK 2018-10-29 /pmc/articles/PMC6206127/ /pubmed/30374195 http://dx.doi.org/10.1038/s41598-018-34411-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ustulin, Morena
Rhee, Sang Youl
Chon, Suk
Ahn, Kyu Keung
Lim, Ji Eun
Oh, Bermseok
Kim, Sung-Hoon
Baik, Sei Hyun
Park, Yongsoo
Nam, Moon Suk
Lee, Kwan Woo
Kim, Young Seol
Woo, Jeong-Taek
Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population
title Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population
title_full Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population
title_fullStr Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population
title_full_unstemmed Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population
title_short Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population
title_sort importance of family history of diabetes in computing a diabetes risk score in korean prediabetic population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206127/
https://www.ncbi.nlm.nih.gov/pubmed/30374195
http://dx.doi.org/10.1038/s41598-018-34411-w
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