Cargando…

Marek’s Disease Virus Activates the PI3K/Akt Pathway Through Interaction of Its Protein Meq With the P85 Subunit of PI3K to Promote Viral Replication

It is known that viruses can active the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway in host cells to support cell survival and viral replication; however, the role of PI3K/Akt signaling in the pathogenic mechanisms induced by Marek’s disease virus (MDV) which causes a neoplastic Marek...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Huimin, Zhu, Jiaojiao, He, Minyi, Luo, Qiong, Liu, Fan, Chen, Ruiai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206265/ https://www.ncbi.nlm.nih.gov/pubmed/30405592 http://dx.doi.org/10.3389/fmicb.2018.02547

Ejemplares similares

Attenuation of a recombinant Marek's disease virus lacking the meq oncogene and evaluation on its immune efficacy against Marek's disease virus
por: Sun, Peng, et al.
Publicado: (2020)

Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit
por: Shriver, Marey, et al.
Publicado: (2016)

HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis
por: Dunn, Ewan F., et al.
Publicado: (2012)

Study of the K+K-pi+pi- system centrally produced in the reactions pi+p --> pi+(K+K-pi+pi-)p and pp --> p(K+K-pi+pi-)p at 85 GeV/c
por: Armstrong, T A, et al.
Publicado: (1986)

Research Note: Characterization of S-Meq containing the deletion in Meq protein's transactivation domain in a Marek's disease virus strain in Japan
por: Murata, Shiro, et al.
Publicado: (2021)

PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits
por: Wang, Qi, et al.
Publicado: (2020)

Positive Selection Drives Rapid Evolution of the meq Oncogene of Marek’s Disease Virus
por: Padhi, Abinash, et al.
Publicado: (2016)

Sequence analysis of Meq oncogene among Indian isolates of Marek's disease herpesvirus
por: Gupta, Mridula, et al.
Publicado: (2016)

Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit
por: Neal, Christopher L., et al.
Publicado: (2011)

Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K
por: Conley, Mary Ellen, et al.
Publicado: (2012)

Diversity of Meq gene from clinical Marek’s disease virus infection in Saudi Arabia
por: Mohamed, Mahmoud H. A., et al.
Publicado: (2016)

The regulatory subunits of PI3K, p85α and p85β, differentially affect BRD7-mediated regulation of insulin signaling
por: Lee, Junsik M, et al.
Publicado: (2021)

Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β
por: Ito, Yoshihiro, et al.
Publicado: (2017)

Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin
por: Ni, Duan, et al.
Publicado: (2018)

PI3K/AKT Pathway and Brain Malformations
por: Rice, Gavin B., et al.
Publicado: (2015)

PI3K and AKT: Unfaithful Partners in Cancer
por: Faes, Seraina, et al.
Publicado: (2015)

The PI3K/Akt Pathway in Meta-Inflammation
por: Acosta-Martinez, Maricedes, et al.
Publicado: (2022)

Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells
por: TIAN, FENG, et al.
Publicado: (2015)

Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells
por: Tian, Feng, et al.
Publicado: (2023)

IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways
por: Duan, Shiyu, et al.
Publicado: (2018)

Study of the centrally produced $\pi\pi$ and $K\bar{K}$ systems at 85 and 300 GeV/c
por: Armstrong, T A, et al.
Publicado: (1991)

Make Yourself at Home: Viral Hijacking of the PI3K/Akt Signaling Pathway
por: Diehl, Nora, et al.
Publicado: (2013)

Deletion of the meq gene significantly decreases immunosuppression in chickens caused by pathogenic marek's disease virus
por: Li, Yanpeng, et al.
Publicado: (2011)

Transcriptional Profiling of MEq-Dependent Genes in Marek’s Disease Resistant and Susceptible Inbred Chicken Lines
por: Subramaniam, Sugalesini, et al.
Publicado: (2013)

Deletion of the Viral Thymidine Kinase in a Meq-Deleted Recombinant Marek’s Disease Virus Reduces Lymphoid Atrophy but Is Less Protective
por: Conrad, Steven J., et al.
Publicado: (2021)

LSD1 Activates PI3K/AKT Signaling Through Regulating p85 Expression in Prostate Cancer Cells
por: Wang, Zifeng, et al.
Publicado: (2019)

NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis
por: Zhi, Feng, et al.
Publicado: (2023)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

The PI3K/Akt Pathway in Tumors of Endocrine Tissues
por: Robbins, Helen Louise, et al.
Publicado: (2016)

Modulation of telomere protection by the PI3K/AKT pathway
por: Méndez-Pertuz, Marinela, et al.
Publicado: (2017)

The effects of Ginsenosides on PI3K/AKT signaling pathway
por: Ghafouri-Fard, Soudeh, et al.
Publicado: (2022)

Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes
por: Mazzon, Michela, et al.
Publicado: (2018)

Frequent copy number variations of PI3K/AKT pathway and aberrant protein expressions of PI3K subunits are associated with inferior survival in diffuse large B cell lymphoma
por: Cui, Wenli, et al.
Publicado: (2014)

The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities
por: Deng, Xufang, et al.
Publicado: (2010)

Newly detected mutations in the Meq oncogene and molecular pathotyping of very virulent Marek’s disease herpesvirus in Tunisia
por: Lachheb, Jihene, et al.
Publicado: (2020)

Getting the Akt Together: Guiding Intracellular Akt Activity by PI3K
por: Yudushkin, Ivan
Publicado: (2019)

Tollip promotes hepatocellular carcinoma progression via PI3K/AKT pathway
por: Huang, Lu, et al.
Publicado: (2022)

K-ras/PI3K-Akt Signaling Is Essential for Zebrafish Hematopoiesis and Angiogenesis
por: Liu, Lihui, et al.
Publicado: (2008)

Recruitment of Vps34 PI3K and enrichment of PI3P phosphoinositide in the viral replication compartment is crucial for replication of a positive-strand RNA virus
por: Feng, Zhike, et al.
Publicado: (2019)

Selection Study for B+- -> (K-+ pi+- pi-+ pi+-)D K+- and B+- -> (K+ K- pi+ pi-)D K+-".
por: Hunt, P, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_vpqhc8dgkib45ag6378t0rptji