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Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation
Cytomegalovirus (CMV) remains a major cause of morbidity following allogeneic hematopoietic stem cell transplant. Natural killer cells expressing NKG2C have been shown to play a role in the immune surveillance of human CMV. We studied NKG2C copy number in the donor graft and the risk of CMV reactiva...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206267/ https://www.ncbi.nlm.nih.gov/pubmed/30405633 http://dx.doi.org/10.3389/fimmu.2018.02444 |
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author | Cao, Kai Marin, David Sekine, Takuye Rondon, Gabriela Zhao, Weicheng Smith, Nathaniel T. Daher, May Wang, Qing Li, Li Saliba, Rima M. Pingali, Ravi Popat, Uday Hosing, Chitra Olson, Amanda Oran, Betul Basar, Rafet Mehta, Rohtesh S. Champlin, Richard Shpall, Elizabeth J. Rezvani, Katayoun |
author_facet | Cao, Kai Marin, David Sekine, Takuye Rondon, Gabriela Zhao, Weicheng Smith, Nathaniel T. Daher, May Wang, Qing Li, Li Saliba, Rima M. Pingali, Ravi Popat, Uday Hosing, Chitra Olson, Amanda Oran, Betul Basar, Rafet Mehta, Rohtesh S. Champlin, Richard Shpall, Elizabeth J. Rezvani, Katayoun |
author_sort | Cao, Kai |
collection | PubMed |
description | Cytomegalovirus (CMV) remains a major cause of morbidity following allogeneic hematopoietic stem cell transplant. Natural killer cells expressing NKG2C have been shown to play a role in the immune surveillance of human CMV. We studied NKG2C copy number in the donor graft and the risk of CMV reactivation after double umbilical cord blood transplantation (DUCBT) in 100 CMV seropositive DUCBT recipients and their corresponding cord blood (CB) grafts (n = 200). In the setting of DUCBT, the combined graft may contain 0–4 functional copies of NKG2C gene. Sixteen patients received a combined graft with 1 or 2 NKG2C copies and 84 patients were recipients of a combined graft with 3 or 4 NKG2C copies. The 6-month cumulative incidence of CMV reactivation for the two groups was 93.7 and 58.4%, respectively (p = 0.0003). In multivariate analysis, low NKG2C copies in the graft was an independent predictor of CMV reactivation (HR = 2.72, CI = 1.59–4.64; p < 0.0001). Our study points to an important role for donor NKG2C for protection against CMV reactivation after DUCBT. These novel findings may help identify patients at a higher risk of CMV reactivation after DUCBT. Donor NKG2C genotype may be used as a potential criterion in the algorithm for graft selection for DUCBT. |
format | Online Article Text |
id | pubmed-6206267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62062672018-11-07 Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation Cao, Kai Marin, David Sekine, Takuye Rondon, Gabriela Zhao, Weicheng Smith, Nathaniel T. Daher, May Wang, Qing Li, Li Saliba, Rima M. Pingali, Ravi Popat, Uday Hosing, Chitra Olson, Amanda Oran, Betul Basar, Rafet Mehta, Rohtesh S. Champlin, Richard Shpall, Elizabeth J. Rezvani, Katayoun Front Immunol Immunology Cytomegalovirus (CMV) remains a major cause of morbidity following allogeneic hematopoietic stem cell transplant. Natural killer cells expressing NKG2C have been shown to play a role in the immune surveillance of human CMV. We studied NKG2C copy number in the donor graft and the risk of CMV reactivation after double umbilical cord blood transplantation (DUCBT) in 100 CMV seropositive DUCBT recipients and their corresponding cord blood (CB) grafts (n = 200). In the setting of DUCBT, the combined graft may contain 0–4 functional copies of NKG2C gene. Sixteen patients received a combined graft with 1 or 2 NKG2C copies and 84 patients were recipients of a combined graft with 3 or 4 NKG2C copies. The 6-month cumulative incidence of CMV reactivation for the two groups was 93.7 and 58.4%, respectively (p = 0.0003). In multivariate analysis, low NKG2C copies in the graft was an independent predictor of CMV reactivation (HR = 2.72, CI = 1.59–4.64; p < 0.0001). Our study points to an important role for donor NKG2C for protection against CMV reactivation after DUCBT. These novel findings may help identify patients at a higher risk of CMV reactivation after DUCBT. Donor NKG2C genotype may be used as a potential criterion in the algorithm for graft selection for DUCBT. Frontiers Media S.A. 2018-10-23 /pmc/articles/PMC6206267/ /pubmed/30405633 http://dx.doi.org/10.3389/fimmu.2018.02444 Text en Copyright © 2018 Cao, Marin, Sekine, Rondon, Zhao, Smith, Daher, Wang, Li, Saliba, Pingali, Popat, Hosing, Olson, Oran, Basar, Mehta, Champlin, Shpall and Rezvani. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Cao, Kai Marin, David Sekine, Takuye Rondon, Gabriela Zhao, Weicheng Smith, Nathaniel T. Daher, May Wang, Qing Li, Li Saliba, Rima M. Pingali, Ravi Popat, Uday Hosing, Chitra Olson, Amanda Oran, Betul Basar, Rafet Mehta, Rohtesh S. Champlin, Richard Shpall, Elizabeth J. Rezvani, Katayoun Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation |
title | Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation |
title_full | Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation |
title_fullStr | Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation |
title_full_unstemmed | Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation |
title_short | Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation |
title_sort | donor nkg2c copy number: an independent predictor for cmv reactivation after double cord blood transplantation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206267/ https://www.ncbi.nlm.nih.gov/pubmed/30405633 http://dx.doi.org/10.3389/fimmu.2018.02444 |
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