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Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes and Neighboring Endogenous Genes

Transgenic mouse lines are routinely employed to label and manipulate distinct cell types. The transgene generally comprises cell-type specific regulatory elements linked to a cDNA encoding a reporter or other protein. However, off-target expression seemingly unrelated to the regulatory elements in...

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Detalles Bibliográficos
Autores principales:	Laboulaye, Mallory A., Duan, Xin, Qiao, Mu, Whitney, Irene E., Sanes, Joshua R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206269/ https://www.ncbi.nlm.nih.gov/pubmed/30405348 http://dx.doi.org/10.3389/fnmol.2018.00385

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