Histopathological and functional changes in a single-dose model of combretastatin A4 disodium phosphate-induced myocardial damage in rats

Cardiotoxicity is a concern in the development of microtubule-disassembling agents (MDAs) as vascular-disrupting agents of tumors. This study investigated cardiotoxicity in rats induced by a single-dose of combretastatin A4 disodium phosphate (CA4DP), an MDA and discussed the use of this rat model i...

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Detalles Bibliográficos
Autores principales: Tochinai, Ryota, Komatsu, Kayoko, Murakami, Junta, Nagata, Yuriko, Ando, Minoru, Hata, Chie, Suzuki, Tomo, Kado, Shoichi, Kobayashi, Toshihide, Kuwahara, Masayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206283/
https://www.ncbi.nlm.nih.gov/pubmed/30393435
http://dx.doi.org/10.1293/tox.2018-0023

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