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Interaction Between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study
Background: We aimed to investigate the interaction between prediabetes and the ABO blood types in predicting esophageal squamous cell carcinoma (ESCC)-specific mortality by analysing data from the FIESTA study on normal/prediabetic patients with ESCC. Methods: Total 1,857 normal/prediabetic patient...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206301/ https://www.ncbi.nlm.nih.gov/pubmed/30406028 http://dx.doi.org/10.3389/fonc.2018.00461 |
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author | Fan, Guohui Hu, Dan Zhang, Xinran Peng, Feng Lin, Xiandong Chen, Gang Liang, Binying Zhang, Hejun Xia, Yan Zheng, Xiongwei Jie, Jianzheng Niu, Wenquan |
author_facet | Fan, Guohui Hu, Dan Zhang, Xinran Peng, Feng Lin, Xiandong Chen, Gang Liang, Binying Zhang, Hejun Xia, Yan Zheng, Xiongwei Jie, Jianzheng Niu, Wenquan |
author_sort | Fan, Guohui |
collection | PubMed |
description | Background: We aimed to investigate the interaction between prediabetes and the ABO blood types in predicting esophageal squamous cell carcinoma (ESCC)-specific mortality by analysing data from the FIESTA study on normal/prediabetic patients with ESCC. Methods: Total 1,857 normal/prediabetic patients with ESCC who underwent three-field lymphadenectomy between January 2000 and December 2010 and survived hospitalization were analyzable, with follow-up beginning in 2000 and ending in 2015. Results: At the end of the follow-up, there were 1,161 survivors and 696 non-survivors. The follow-up time ranged from 0.5 to 180 months. The cumulative survival rates in normal patients were obviously better than in prediabetic patients. The cumulative survival rates were significantly higher in normal patients than in prediabetic patients for the blood types O and A (Log-rank test P < 0.05), while no significance was detected for the blood types B and AB. Adjusted risk estimates for ESCC-specific mortality for prediabetic patients relative to normal patients were statistically significant in the blood type B(−) group (hazard ratio [HR]: 1.71; 95% confidence interval [CI]: 1.33–2.20; P < 0.001), but not in the blood type B(+) group (HR: 1.12; 95% CI: 0.77–1.64; P = 0.5544). Conclusions: Our findings indicate that prediabetes can predict the significant risk of ESCC-specific mortality in Chinese Han patients with the blood types O and A. |
format | Online Article Text |
id | pubmed-6206301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62063012018-11-07 Interaction Between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study Fan, Guohui Hu, Dan Zhang, Xinran Peng, Feng Lin, Xiandong Chen, Gang Liang, Binying Zhang, Hejun Xia, Yan Zheng, Xiongwei Jie, Jianzheng Niu, Wenquan Front Oncol Oncology Background: We aimed to investigate the interaction between prediabetes and the ABO blood types in predicting esophageal squamous cell carcinoma (ESCC)-specific mortality by analysing data from the FIESTA study on normal/prediabetic patients with ESCC. Methods: Total 1,857 normal/prediabetic patients with ESCC who underwent three-field lymphadenectomy between January 2000 and December 2010 and survived hospitalization were analyzable, with follow-up beginning in 2000 and ending in 2015. Results: At the end of the follow-up, there were 1,161 survivors and 696 non-survivors. The follow-up time ranged from 0.5 to 180 months. The cumulative survival rates in normal patients were obviously better than in prediabetic patients. The cumulative survival rates were significantly higher in normal patients than in prediabetic patients for the blood types O and A (Log-rank test P < 0.05), while no significance was detected for the blood types B and AB. Adjusted risk estimates for ESCC-specific mortality for prediabetic patients relative to normal patients were statistically significant in the blood type B(−) group (hazard ratio [HR]: 1.71; 95% confidence interval [CI]: 1.33–2.20; P < 0.001), but not in the blood type B(+) group (HR: 1.12; 95% CI: 0.77–1.64; P = 0.5544). Conclusions: Our findings indicate that prediabetes can predict the significant risk of ESCC-specific mortality in Chinese Han patients with the blood types O and A. Frontiers Media S.A. 2018-10-23 /pmc/articles/PMC6206301/ /pubmed/30406028 http://dx.doi.org/10.3389/fonc.2018.00461 Text en Copyright © 2018 Fan, Hu, Zhang, Peng, Lin, Chen, Liang, Zhang, Xia, Zheng, Jie and Niu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Fan, Guohui Hu, Dan Zhang, Xinran Peng, Feng Lin, Xiandong Chen, Gang Liang, Binying Zhang, Hejun Xia, Yan Zheng, Xiongwei Jie, Jianzheng Niu, Wenquan Interaction Between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study |
title | Interaction Between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study |
title_full | Interaction Between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study |
title_fullStr | Interaction Between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study |
title_full_unstemmed | Interaction Between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study |
title_short | Interaction Between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study |
title_sort | interaction between prediabetes and the abo blood types in predicting postsurgical esophageal squamous cell carcinoma-specific mortality: the fiesta study |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206301/ https://www.ncbi.nlm.nih.gov/pubmed/30406028 http://dx.doi.org/10.3389/fonc.2018.00461 |
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