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Impact of functional inorganic nanotubes f-INTs-WS(2) on hemolysis, platelet function and coagulation

Inorganic transition metal dichalcogenide nanostructures are interesting for several biomedical applications such as coating for medical devices (e.g. endodontic files, catheter stents) and reinforcement of scaffolds for tissue engineering. However, their impact on human blood is unknown. A unique n...

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Autores principales: Laloy, Julie, Haguet, Hélène, Alpan, Lutfiye, Raichman, Daniel, Dogné, Jean-Michel, Lellouche, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206311/
https://www.ncbi.nlm.nih.gov/pubmed/30467733
http://dx.doi.org/10.1186/s40580-018-0162-1
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author Laloy, Julie
Haguet, Hélène
Alpan, Lutfiye
Raichman, Daniel
Dogné, Jean-Michel
Lellouche, Jean-Paul
author_facet Laloy, Julie
Haguet, Hélène
Alpan, Lutfiye
Raichman, Daniel
Dogné, Jean-Michel
Lellouche, Jean-Paul
author_sort Laloy, Julie
collection PubMed
description Inorganic transition metal dichalcogenide nanostructures are interesting for several biomedical applications such as coating for medical devices (e.g. endodontic files, catheter stents) and reinforcement of scaffolds for tissue engineering. However, their impact on human blood is unknown. A unique nanomaterial surface-engineering chemical methodology was used to fabricate functional polyacidic polyCOOH inorganic nanotubes of tungsten disulfide towards covalent binding of any desired molecule/organic species via chemical activation/reactivity of this former polyCOOH shell. The impact of these nanotubes on hemolysis, platelet aggregation and blood coagulation has been assessed using spectrophotometric measurement, light transmission aggregometry and thrombin generation assays. The functionalized nanotubes do not induce hemolysis but decrease platelet aggregation and induce coagulation through intrinsic pathway activation. The functional nanotubes were found to be more thrombogenic than the non-functional ones, suggesting lower hemocompatibility and increased thrombotic risk with functionalized tungsten disulfide nanotubes. These functionalized nanotubes should be used with caution in blood-contacting devices.
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spelling pubmed-62063112018-11-15 Impact of functional inorganic nanotubes f-INTs-WS(2) on hemolysis, platelet function and coagulation Laloy, Julie Haguet, Hélène Alpan, Lutfiye Raichman, Daniel Dogné, Jean-Michel Lellouche, Jean-Paul Nano Converg Research Inorganic transition metal dichalcogenide nanostructures are interesting for several biomedical applications such as coating for medical devices (e.g. endodontic files, catheter stents) and reinforcement of scaffolds for tissue engineering. However, their impact on human blood is unknown. A unique nanomaterial surface-engineering chemical methodology was used to fabricate functional polyacidic polyCOOH inorganic nanotubes of tungsten disulfide towards covalent binding of any desired molecule/organic species via chemical activation/reactivity of this former polyCOOH shell. The impact of these nanotubes on hemolysis, platelet aggregation and blood coagulation has been assessed using spectrophotometric measurement, light transmission aggregometry and thrombin generation assays. The functionalized nanotubes do not induce hemolysis but decrease platelet aggregation and induce coagulation through intrinsic pathway activation. The functional nanotubes were found to be more thrombogenic than the non-functional ones, suggesting lower hemocompatibility and increased thrombotic risk with functionalized tungsten disulfide nanotubes. These functionalized nanotubes should be used with caution in blood-contacting devices. Springer Singapore 2018-10-30 /pmc/articles/PMC6206311/ /pubmed/30467733 http://dx.doi.org/10.1186/s40580-018-0162-1 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Laloy, Julie
Haguet, Hélène
Alpan, Lutfiye
Raichman, Daniel
Dogné, Jean-Michel
Lellouche, Jean-Paul
Impact of functional inorganic nanotubes f-INTs-WS(2) on hemolysis, platelet function and coagulation
title Impact of functional inorganic nanotubes f-INTs-WS(2) on hemolysis, platelet function and coagulation
title_full Impact of functional inorganic nanotubes f-INTs-WS(2) on hemolysis, platelet function and coagulation
title_fullStr Impact of functional inorganic nanotubes f-INTs-WS(2) on hemolysis, platelet function and coagulation
title_full_unstemmed Impact of functional inorganic nanotubes f-INTs-WS(2) on hemolysis, platelet function and coagulation
title_short Impact of functional inorganic nanotubes f-INTs-WS(2) on hemolysis, platelet function and coagulation
title_sort impact of functional inorganic nanotubes f-ints-ws(2) on hemolysis, platelet function and coagulation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206311/
https://www.ncbi.nlm.nih.gov/pubmed/30467733
http://dx.doi.org/10.1186/s40580-018-0162-1
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