Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform

Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated Wik...

Descripción completa

Detalles Bibliográficos
Autores principales: Miller, Ryan A., Woollard, Peter, Willighagen, Egon L., Digles, Daniela, Kutmon, Martina, Loizou, Antonis, Waagmeester, Andra, Senger, Stefan, Evelo, Chris T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Software Tool Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206606/
https://www.ncbi.nlm.nih.gov/pubmed/30416713
http://dx.doi.org/10.12688/f1000research.13197.2
Descripción
Sumario:Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological interactions, such as stimulation and inhibition. The platform's Application Programming Interface (API) was extended with appropriate calls to reference these interactions.  These new methods of the Open PHACTS API are available now.

Ejemplares similares