Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform

Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated Wik...

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Autores principales: Miller, Ryan A., Woollard, Peter, Willighagen, Egon L., Digles, Daniela, Kutmon, Martina, Loizou, Antonis, Waagmeester, Andra, Senger, Stefan, Evelo, Chris T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Software Tool Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206606/
https://www.ncbi.nlm.nih.gov/pubmed/30416713
http://dx.doi.org/10.12688/f1000research.13197.2
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author Miller, Ryan A.
Woollard, Peter
Willighagen, Egon L.
Digles, Daniela
Kutmon, Martina
Loizou, Antonis
Waagmeester, Andra
Senger, Stefan
Evelo, Chris T.
author_facet Miller, Ryan A.
Woollard, Peter
Willighagen, Egon L.
Digles, Daniela
Kutmon, Martina
Loizou, Antonis
Waagmeester, Andra
Senger, Stefan
Evelo, Chris T.
author_sort Miller, Ryan A.
collection PubMed
description Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological interactions, such as stimulation and inhibition. The platform's Application Programming Interface (API) was extended with appropriate calls to reference these interactions.  These new methods of the Open PHACTS API are available now.
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spelling pubmed-62066062018-11-09 Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform Miller, Ryan A. Woollard, Peter Willighagen, Egon L. Digles, Daniela Kutmon, Martina Loizou, Antonis Waagmeester, Andra Senger, Stefan Evelo, Chris T. F1000Res Software Tool Article Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological interactions, such as stimulation and inhibition. The platform's Application Programming Interface (API) was extended with appropriate calls to reference these interactions.  These new methods of the Open PHACTS API are available now. F1000 Research Limited 2018-10-12 /pmc/articles/PMC6206606/ /pubmed/30416713 http://dx.doi.org/10.12688/f1000research.13197.2 Text en Copyright: © 2018 Miller RA et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Software Tool Article
Miller, Ryan A.
Woollard, Peter
Willighagen, Egon L.
Digles, Daniela
Kutmon, Martina
Loizou, Antonis
Waagmeester, Andra
Senger, Stefan
Evelo, Chris T.
Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform
title Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform
title_full Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform
title_fullStr Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform
title_full_unstemmed Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform
title_short Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform
title_sort explicit interaction information from wikipathways in rdf facilitates drug discovery in the open phacts discovery platform
topic Software Tool Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206606/
https://www.ncbi.nlm.nih.gov/pubmed/30416713
http://dx.doi.org/10.12688/f1000research.13197.2
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