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Detection of phosphorothioated (PS) oligonucleotides in horse plasma using a product ion (m/z 94.9362) derived from the PS moiety for doping control

OBJECTIVE: Clinical research on gene therapy has advanced the field of veterinary medicine, and gene doping, which is the illegal use of gene therapy, has become a major concern in horseracing. Since the International Federation of Horseracing Authorities defined the administration of oligonucleotid...

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Detalles Bibliográficos
Autores principales: Tozaki, Teruaki, Karasawa, Kaoru, Minamijima, Yohei, Ishii, Hideaki, Kikuchi, Mio, Kakoi, Hironaga, Hirota, Kei-ichi, Kusano, Kanichi, Nagata, Shun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206624/
https://www.ncbi.nlm.nih.gov/pubmed/30373660
http://dx.doi.org/10.1186/s13104-018-3885-5