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Long-term follow-up in adults after tetralogy of Fallot repair
BACKGROUND: Tetralogy of Fallot (ToF) is the most common cyanotic congenital heart disease and the population of ToF repair survivors is growing rapidly. Adults with repaired ToF develop late complications. The aim of this study was to describe and analyze long-term follow-up of patients with repair...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206664/ https://www.ncbi.nlm.nih.gov/pubmed/30373624 http://dx.doi.org/10.1186/s12947-018-0146-7 |
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author | Dłużniewska, Natalia Podolec, Piotr Skubera, Maciej Smaś-Suska, Monika Pająk, Jacek Urbańczyk-Zawadzka, Małgorzata Płazak, Wojciech Olszowska, Maria Tomkiewicz-Pająk, Lidia |
author_facet | Dłużniewska, Natalia Podolec, Piotr Skubera, Maciej Smaś-Suska, Monika Pająk, Jacek Urbańczyk-Zawadzka, Małgorzata Płazak, Wojciech Olszowska, Maria Tomkiewicz-Pająk, Lidia |
author_sort | Dłużniewska, Natalia |
collection | PubMed |
description | BACKGROUND: Tetralogy of Fallot (ToF) is the most common cyanotic congenital heart disease and the population of ToF repair survivors is growing rapidly. Adults with repaired ToF develop late complications. The aim of this study was to describe and analyze long-term follow-up of patients with repaired ToF. METHODS: This is a retrospective cohort study. Consecutive 83 patients with repaired ToF who did not undergo pulmonary valve replacement were included. Mean age of all patients was 30.5 ± 10.7. There were 49 (59%) male. Patients were divided into two groups according to the time since the repair (< 25 years and ≥ 25 years). The electrocardiographic (ECG), cardiopulmonary exercise testing (CPET), echocardiographic and cardiac magnetic resonance (CMR) data were reviewed retrospectively. RESULTS: In CPET values were not significantly different in the two groups. In CMR volumes of left and right ventricles were not significantly different in the two groups. There were no differences between the groups in ventricular ejection fraction, mass of ventricles, or pulmonary regurgitation fraction. Among all the patients, ejection fraction and left and right ventricle mass, indexed pulmonary regurgitation volume measured by CMR did not correlate with the time since repair. In ECG among all the patients, ejection fraction of the RV, measured in CMR, negatively correlated with QRS duration (r = − 0.43; p < 0.001). There was a positive correlation between QRS duration and end diastolic volume of the RV (r = 0.30; p < 0.02), indexed end diastolic volume of the RV (r = 0.29; p = 0.04), RV mass (r = 0.36; p < 0.001) and left ventricle mass (r = 0.26; p = 0.04). CONCLUSION: Long-term survival and clinical condition after surgical correction of ToF in infancy is generally good and the late functional status in ToF – operated patients could be excellent up to 25 years after the repair. QRS duration could be an utility and easy factor to assessment of right ventricular function. TRIAL REGISTRATION: The study protocol was approved by the local Ethics Committee. Each participant provided informed consent to participate in the study (license number 122.6120.88.2016 from 28.04.2016). |
format | Online Article Text |
id | pubmed-6206664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62066642018-10-31 Long-term follow-up in adults after tetralogy of Fallot repair Dłużniewska, Natalia Podolec, Piotr Skubera, Maciej Smaś-Suska, Monika Pająk, Jacek Urbańczyk-Zawadzka, Małgorzata Płazak, Wojciech Olszowska, Maria Tomkiewicz-Pająk, Lidia Cardiovasc Ultrasound Research BACKGROUND: Tetralogy of Fallot (ToF) is the most common cyanotic congenital heart disease and the population of ToF repair survivors is growing rapidly. Adults with repaired ToF develop late complications. The aim of this study was to describe and analyze long-term follow-up of patients with repaired ToF. METHODS: This is a retrospective cohort study. Consecutive 83 patients with repaired ToF who did not undergo pulmonary valve replacement were included. Mean age of all patients was 30.5 ± 10.7. There were 49 (59%) male. Patients were divided into two groups according to the time since the repair (< 25 years and ≥ 25 years). The electrocardiographic (ECG), cardiopulmonary exercise testing (CPET), echocardiographic and cardiac magnetic resonance (CMR) data were reviewed retrospectively. RESULTS: In CPET values were not significantly different in the two groups. In CMR volumes of left and right ventricles were not significantly different in the two groups. There were no differences between the groups in ventricular ejection fraction, mass of ventricles, or pulmonary regurgitation fraction. Among all the patients, ejection fraction and left and right ventricle mass, indexed pulmonary regurgitation volume measured by CMR did not correlate with the time since repair. In ECG among all the patients, ejection fraction of the RV, measured in CMR, negatively correlated with QRS duration (r = − 0.43; p < 0.001). There was a positive correlation between QRS duration and end diastolic volume of the RV (r = 0.30; p < 0.02), indexed end diastolic volume of the RV (r = 0.29; p = 0.04), RV mass (r = 0.36; p < 0.001) and left ventricle mass (r = 0.26; p = 0.04). CONCLUSION: Long-term survival and clinical condition after surgical correction of ToF in infancy is generally good and the late functional status in ToF – operated patients could be excellent up to 25 years after the repair. QRS duration could be an utility and easy factor to assessment of right ventricular function. TRIAL REGISTRATION: The study protocol was approved by the local Ethics Committee. Each participant provided informed consent to participate in the study (license number 122.6120.88.2016 from 28.04.2016). BioMed Central 2018-10-29 /pmc/articles/PMC6206664/ /pubmed/30373624 http://dx.doi.org/10.1186/s12947-018-0146-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Dłużniewska, Natalia Podolec, Piotr Skubera, Maciej Smaś-Suska, Monika Pająk, Jacek Urbańczyk-Zawadzka, Małgorzata Płazak, Wojciech Olszowska, Maria Tomkiewicz-Pająk, Lidia Long-term follow-up in adults after tetralogy of Fallot repair |
title | Long-term follow-up in adults after tetralogy of Fallot repair |
title_full | Long-term follow-up in adults after tetralogy of Fallot repair |
title_fullStr | Long-term follow-up in adults after tetralogy of Fallot repair |
title_full_unstemmed | Long-term follow-up in adults after tetralogy of Fallot repair |
title_short | Long-term follow-up in adults after tetralogy of Fallot repair |
title_sort | long-term follow-up in adults after tetralogy of fallot repair |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206664/ https://www.ncbi.nlm.nih.gov/pubmed/30373624 http://dx.doi.org/10.1186/s12947-018-0146-7 |
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