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Reference intervals for hemoglobin A1c (HbA1c) in healthy Mexican pregnant women: a cross-sectional study

BACKGROUND: The reference intervals for hemoglobin A1c (HbA1c) in pregnant Mexican women without diabetes are not well defined. The study aims to determine the reference intervals for HbA1c at each trimester in healthy Mexican pregnant women. METHODS: This cross-sectional study included healthy Mexi...

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Autores principales: Sánchez-González, Cristina M., Castillo-Mora, Alfredo, Alvarado-Maldonado, Itzel N., Ortega-González, Carlos, Martínez-Cruz, Nayeli, Arce-Sánchez, Lidia, Ramos-Valencia, Mabel, Molina-Hernández, Anayansi, Estrada-Gutierrez, Guadalupe, Sosa, Salvador Espino Y., Recio-López, Yesenia, Hernández-Sánchez, Ruth, Reyes-Muñoz, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206911/
https://www.ncbi.nlm.nih.gov/pubmed/30373541
http://dx.doi.org/10.1186/s12884-018-2057-x
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author Sánchez-González, Cristina M.
Castillo-Mora, Alfredo
Alvarado-Maldonado, Itzel N.
Ortega-González, Carlos
Martínez-Cruz, Nayeli
Arce-Sánchez, Lidia
Ramos-Valencia, Mabel
Molina-Hernández, Anayansi
Estrada-Gutierrez, Guadalupe
Sosa, Salvador Espino Y.
Recio-López, Yesenia
Hernández-Sánchez, Ruth
Reyes-Muñoz, Enrique
author_facet Sánchez-González, Cristina M.
Castillo-Mora, Alfredo
Alvarado-Maldonado, Itzel N.
Ortega-González, Carlos
Martínez-Cruz, Nayeli
Arce-Sánchez, Lidia
Ramos-Valencia, Mabel
Molina-Hernández, Anayansi
Estrada-Gutierrez, Guadalupe
Sosa, Salvador Espino Y.
Recio-López, Yesenia
Hernández-Sánchez, Ruth
Reyes-Muñoz, Enrique
author_sort Sánchez-González, Cristina M.
collection PubMed
description BACKGROUND: The reference intervals for hemoglobin A1c (HbA1c) in pregnant Mexican women without diabetes are not well defined. The study aims to determine the reference intervals for HbA1c at each trimester in healthy Mexican pregnant women. METHODS: This cross-sectional study included healthy Mexican pregnant women in trimester 1 (T1), 6–13.6 weeks of gestation (WG), trimester 2 (T2), 14–27 WG, and trimester 3 (T3), ≥27–36 WG, with a maternal age > 18 years, and pregestational body mass index (BMI) ranging between 18.5–24.9 kg/m(2). Women with gestational diabetes mellitus, pregestational diabetes, anemia, a pregestational BMI < 18.5 or ≥ 25 kg/m(2), and any hematologic, hepatic, immunological, renal, or cardiac disease were excluded. HbA1c was measured using high-performance liquid chromatography based on the National Glycohemoglobin Standardization Program-certified PDQ Primus guidelines. The HbA1c reference intervals were calculated in terms of the 2.5th to the 97.5th percentiles. RESULTS: We analyzed the HbA1c values of 725 women (T1 n = 84, T2 n = 448, and T3 n = 193). The characteristics of the participants were expressed as mean ± standard deviation and included: maternal age (28.2 ± 6.7 years), pregestational weight (54.8 ± 5.9 Kg), pregestational BMI (22.2 ± 1.7 Kg/m(2)), and glucose values using a 75 g-2 h oral glucose tolerance test; fasting 4.5 ± 0.3 mmol/L (81.5 ± 5.5 mg/dL), 1 h 6.4 ± 1.5 mmol/L (115.3 ± 26.6 mg/dL), and 2 h 5.7 ± 1.1 mmol/L (103.5 ± 19.6 mg/dL). Reference intervals for HbA1c, expressed as median and 2.5th to 97.5th percentile for each trimester were: T1: 5.1 (4.5–5.6%), T2: 5.0 (4.4–5.5%), and T3: 5.1 (4.5–5.6%). CONCLUSIONS: The reference range of HbA1C in healthy Mexican pregnant women during pregnancy was 4.4% to 5.6%. We suggest as upper limits of HbA1c value ≤5.6%, 5.5%, and 5.7% for T1, T2, and T3, respectively among Mexican pregnant women.
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spelling pubmed-62069112018-10-31 Reference intervals for hemoglobin A1c (HbA1c) in healthy Mexican pregnant women: a cross-sectional study Sánchez-González, Cristina M. Castillo-Mora, Alfredo Alvarado-Maldonado, Itzel N. Ortega-González, Carlos Martínez-Cruz, Nayeli Arce-Sánchez, Lidia Ramos-Valencia, Mabel Molina-Hernández, Anayansi Estrada-Gutierrez, Guadalupe Sosa, Salvador Espino Y. Recio-López, Yesenia Hernández-Sánchez, Ruth Reyes-Muñoz, Enrique BMC Pregnancy Childbirth Research Article BACKGROUND: The reference intervals for hemoglobin A1c (HbA1c) in pregnant Mexican women without diabetes are not well defined. The study aims to determine the reference intervals for HbA1c at each trimester in healthy Mexican pregnant women. METHODS: This cross-sectional study included healthy Mexican pregnant women in trimester 1 (T1), 6–13.6 weeks of gestation (WG), trimester 2 (T2), 14–27 WG, and trimester 3 (T3), ≥27–36 WG, with a maternal age > 18 years, and pregestational body mass index (BMI) ranging between 18.5–24.9 kg/m(2). Women with gestational diabetes mellitus, pregestational diabetes, anemia, a pregestational BMI < 18.5 or ≥ 25 kg/m(2), and any hematologic, hepatic, immunological, renal, or cardiac disease were excluded. HbA1c was measured using high-performance liquid chromatography based on the National Glycohemoglobin Standardization Program-certified PDQ Primus guidelines. The HbA1c reference intervals were calculated in terms of the 2.5th to the 97.5th percentiles. RESULTS: We analyzed the HbA1c values of 725 women (T1 n = 84, T2 n = 448, and T3 n = 193). The characteristics of the participants were expressed as mean ± standard deviation and included: maternal age (28.2 ± 6.7 years), pregestational weight (54.8 ± 5.9 Kg), pregestational BMI (22.2 ± 1.7 Kg/m(2)), and glucose values using a 75 g-2 h oral glucose tolerance test; fasting 4.5 ± 0.3 mmol/L (81.5 ± 5.5 mg/dL), 1 h 6.4 ± 1.5 mmol/L (115.3 ± 26.6 mg/dL), and 2 h 5.7 ± 1.1 mmol/L (103.5 ± 19.6 mg/dL). Reference intervals for HbA1c, expressed as median and 2.5th to 97.5th percentile for each trimester were: T1: 5.1 (4.5–5.6%), T2: 5.0 (4.4–5.5%), and T3: 5.1 (4.5–5.6%). CONCLUSIONS: The reference range of HbA1C in healthy Mexican pregnant women during pregnancy was 4.4% to 5.6%. We suggest as upper limits of HbA1c value ≤5.6%, 5.5%, and 5.7% for T1, T2, and T3, respectively among Mexican pregnant women. BioMed Central 2018-10-29 /pmc/articles/PMC6206911/ /pubmed/30373541 http://dx.doi.org/10.1186/s12884-018-2057-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Sánchez-González, Cristina M.
Castillo-Mora, Alfredo
Alvarado-Maldonado, Itzel N.
Ortega-González, Carlos
Martínez-Cruz, Nayeli
Arce-Sánchez, Lidia
Ramos-Valencia, Mabel
Molina-Hernández, Anayansi
Estrada-Gutierrez, Guadalupe
Sosa, Salvador Espino Y.
Recio-López, Yesenia
Hernández-Sánchez, Ruth
Reyes-Muñoz, Enrique
Reference intervals for hemoglobin A1c (HbA1c) in healthy Mexican pregnant women: a cross-sectional study
title Reference intervals for hemoglobin A1c (HbA1c) in healthy Mexican pregnant women: a cross-sectional study
title_full Reference intervals for hemoglobin A1c (HbA1c) in healthy Mexican pregnant women: a cross-sectional study
title_fullStr Reference intervals for hemoglobin A1c (HbA1c) in healthy Mexican pregnant women: a cross-sectional study
title_full_unstemmed Reference intervals for hemoglobin A1c (HbA1c) in healthy Mexican pregnant women: a cross-sectional study
title_short Reference intervals for hemoglobin A1c (HbA1c) in healthy Mexican pregnant women: a cross-sectional study
title_sort reference intervals for hemoglobin a1c (hba1c) in healthy mexican pregnant women: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206911/
https://www.ncbi.nlm.nih.gov/pubmed/30373541
http://dx.doi.org/10.1186/s12884-018-2057-x
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