Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

BACKGROUND: The PD-L1/PD-1 pathway blockade-mediated immune therapy has shown promising efficacy in the treatment of multiple cancers including melanoma. The present study investigated the effects of the flavonoid apigenin on the PD-L1 expression and the tumorigenesis of melanoma. METHODS: The influ...

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Detalles Bibliográficos
Autores principales: Xu, Lu, Zhang, Yang, Tian, Kang, Chen, Xi, Zhang, Rongxin, Mu, Xindi, Wu, Yueguang, Wang, Duchuang, Wang, Shanshan, Liu, Fang, Wang, Taishu, Zhang, Jinrui, Liu, Shuyan, Zhang, Yingqiu, Tu, Caixia, Liu, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206930/
https://www.ncbi.nlm.nih.gov/pubmed/30373602
http://dx.doi.org/10.1186/s13046-018-0929-6

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