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Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status
DNA methylation patterns change with age and can be used to derive an estimate of “epigenetic age,” an indicator of biological age. Several studies have shown associations of posttraumatic stress disorder (PTSD) with worse somatic health and early mortality, raising the possibility of accelerated bi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206951/ https://www.ncbi.nlm.nih.gov/pubmed/30397597 http://dx.doi.org/10.1159/000491431 |
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author | Verhoeven, Josine E. Yang, Ruoting Wolkowitz, Owen M. Bersani, Francesco S. Lindqvist, Daniel Mellon, Synthia H. Yehuda, Rachel Flory, Janine D. Lin, Jue Abu-Amara, Duna Makotkine, Iouri Marmar, Charles Jett, Marti Hammamieh, Rasha |
author_facet | Verhoeven, Josine E. Yang, Ruoting Wolkowitz, Owen M. Bersani, Francesco S. Lindqvist, Daniel Mellon, Synthia H. Yehuda, Rachel Flory, Janine D. Lin, Jue Abu-Amara, Duna Makotkine, Iouri Marmar, Charles Jett, Marti Hammamieh, Rasha |
author_sort | Verhoeven, Josine E. |
collection | PubMed |
description | DNA methylation patterns change with age and can be used to derive an estimate of “epigenetic age,” an indicator of biological age. Several studies have shown associations of posttraumatic stress disorder (PTSD) with worse somatic health and early mortality, raising the possibility of accelerated biological aging. This study examined associations between estimated epigenetic age and various variables in 160 male combat-exposed war veterans with (n = 79) and without PTSD (n = 81). DNA methylation was assessed in leukocyte genomic DNA using the Illumina 450K DNA methylation arrays. Epigenetic age was estimated using Horvath's epigenetic clock algorithm and Δage (epigenetic age-chronological age) was calculated. In veterans with PTSD (Δage = 3.2), Δage was on average lower compared to those without PTSD (Δage = 5.0; p = 0.02; Cohen's d = 0.42). This between-group difference was not explained by race/ethnicity, lifestyle factors or childhood trauma. Antidepressant use, however, explained part of the association. In the PTSD positive group, telomerase activity was negatively related to Δage (β = −0.35; p = 0.007). In conclusion, veterans with PTSD had significantly lower epigenetic age profiles than those without PTSD. Further, current antidepressant use and higher telomerase activity were related to relatively less epigenetic aging in veterans with PTSD, speculative of a mechanistic pathway that might attenuate biological aging-related processes in the context of PTSD. |
format | Online Article Text |
id | pubmed-6206951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-62069512018-11-05 Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status Verhoeven, Josine E. Yang, Ruoting Wolkowitz, Owen M. Bersani, Francesco S. Lindqvist, Daniel Mellon, Synthia H. Yehuda, Rachel Flory, Janine D. Lin, Jue Abu-Amara, Duna Makotkine, Iouri Marmar, Charles Jett, Marti Hammamieh, Rasha Mol Neuropsychiatry Original Paper DNA methylation patterns change with age and can be used to derive an estimate of “epigenetic age,” an indicator of biological age. Several studies have shown associations of posttraumatic stress disorder (PTSD) with worse somatic health and early mortality, raising the possibility of accelerated biological aging. This study examined associations between estimated epigenetic age and various variables in 160 male combat-exposed war veterans with (n = 79) and without PTSD (n = 81). DNA methylation was assessed in leukocyte genomic DNA using the Illumina 450K DNA methylation arrays. Epigenetic age was estimated using Horvath's epigenetic clock algorithm and Δage (epigenetic age-chronological age) was calculated. In veterans with PTSD (Δage = 3.2), Δage was on average lower compared to those without PTSD (Δage = 5.0; p = 0.02; Cohen's d = 0.42). This between-group difference was not explained by race/ethnicity, lifestyle factors or childhood trauma. Antidepressant use, however, explained part of the association. In the PTSD positive group, telomerase activity was negatively related to Δage (β = −0.35; p = 0.007). In conclusion, veterans with PTSD had significantly lower epigenetic age profiles than those without PTSD. Further, current antidepressant use and higher telomerase activity were related to relatively less epigenetic aging in veterans with PTSD, speculative of a mechanistic pathway that might attenuate biological aging-related processes in the context of PTSD. S. Karger AG 2018-10 2018-09-05 /pmc/articles/PMC6206951/ /pubmed/30397597 http://dx.doi.org/10.1159/000491431 Text en Copyright © 2018 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. |
spellingShingle | Original Paper Verhoeven, Josine E. Yang, Ruoting Wolkowitz, Owen M. Bersani, Francesco S. Lindqvist, Daniel Mellon, Synthia H. Yehuda, Rachel Flory, Janine D. Lin, Jue Abu-Amara, Duna Makotkine, Iouri Marmar, Charles Jett, Marti Hammamieh, Rasha Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status |
title | Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status |
title_full | Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status |
title_fullStr | Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status |
title_full_unstemmed | Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status |
title_short | Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status |
title_sort | epigenetic age in male combat-exposed war veterans: associations with posttraumatic stress disorder status |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206951/ https://www.ncbi.nlm.nih.gov/pubmed/30397597 http://dx.doi.org/10.1159/000491431 |
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