Potassium channels in the sinoatrial node and their role in heart rate control

Potassium currents determine the resting membrane potential and govern repolarisation in cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on their molecular and cellular properties and their role in pacemaking and heart rate control. We also describe how our re...

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Detalles Bibliográficos
Autores principales: Aziz, Qadeer, Li, Yiwen, Tinker, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207292/
https://www.ncbi.nlm.nih.gov/pubmed/30301404
http://dx.doi.org/10.1080/19336950.2018.1532255
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author Aziz, Qadeer
Li, Yiwen
Tinker, Andrew
author_facet Aziz, Qadeer
Li, Yiwen
Tinker, Andrew
author_sort Aziz, Qadeer
collection PubMed
description Potassium currents determine the resting membrane potential and govern repolarisation in cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on their molecular and cellular properties and their role in pacemaking and heart rate control. We also describe how our recent finding of a novel ATP-sensitive potassium channel population in these cells fits into this picture.
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spelling pubmed-62072922018-10-31 Potassium channels in the sinoatrial node and their role in heart rate control Aziz, Qadeer Li, Yiwen Tinker, Andrew Channels (Austin) Review Potassium currents determine the resting membrane potential and govern repolarisation in cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on their molecular and cellular properties and their role in pacemaking and heart rate control. We also describe how our recent finding of a novel ATP-sensitive potassium channel population in these cells fits into this picture. Taylor & Francis 2018-10-09 /pmc/articles/PMC6207292/ /pubmed/30301404 http://dx.doi.org/10.1080/19336950.2018.1532255 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Aziz, Qadeer
Li, Yiwen
Tinker, Andrew
Potassium channels in the sinoatrial node and their role in heart rate control
title Potassium channels in the sinoatrial node and their role in heart rate control
title_full Potassium channels in the sinoatrial node and their role in heart rate control
title_fullStr Potassium channels in the sinoatrial node and their role in heart rate control
title_full_unstemmed Potassium channels in the sinoatrial node and their role in heart rate control
title_short Potassium channels in the sinoatrial node and their role in heart rate control
title_sort potassium channels in the sinoatrial node and their role in heart rate control
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207292/
https://www.ncbi.nlm.nih.gov/pubmed/30301404
http://dx.doi.org/10.1080/19336950.2018.1532255
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