Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus

BACKGROUND: The study of the experiment was to display the therapeutic function of insulin-loaded chitosan (insulin/chitosan) on mesenteric microcirculation via down-regulating cyclooxygenase-2 (COX-2) and vascular cell adhesion molecule (VCAM-1) expressions in rats with diabetes mellitus (DM) as co...

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Autores principales: Xu, Jun, Cao, Lijun, Suo, Yuan, Xu, Xiaoqin, Sun, Hui, Xu, Songao, Zhu, Xiangyun, Yu, Huijie, Cao, Weizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207390/
https://www.ncbi.nlm.nih.gov/pubmed/30498345
http://dx.doi.org/10.2147/IJN.S174030
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author Xu, Jun
Cao, Lijun
Suo, Yuan
Xu, Xiaoqin
Sun, Hui
Xu, Songao
Zhu, Xiangyun
Yu, Huijie
Cao, Weizhong
author_facet Xu, Jun
Cao, Lijun
Suo, Yuan
Xu, Xiaoqin
Sun, Hui
Xu, Songao
Zhu, Xiangyun
Yu, Huijie
Cao, Weizhong
author_sort Xu, Jun
collection PubMed
description BACKGROUND: The study of the experiment was to display the therapeutic function of insulin-loaded chitosan (insulin/chitosan) on mesenteric microcirculation via down-regulating cyclooxygenase-2 (COX-2) and vascular cell adhesion molecule (VCAM-1) expressions in rats with diabetes mellitus (DM) as compared to free insulin. METHODS: Diabetic rats were administrated with 24 U/kg insulin or 120 U/kg insulin/chitosan compounds. The blood and mesenteriums were collected, blood glucose levels, arteriole velocity, arteriole diameter, venular diameter, and hemodiapedesis were measured, and COX-2, VCAM-1 expressions were measured in mesenteriums tissues. RESULTS: Both insulin and insulin/chitosan administration decreased blood glucose and improved the state of mesenteric microcirculation through down-regulating COX-2 and VCAM-1 expressions as compared to DM groups, while insulin/chitosan remarkably augmented this functions. CONCLUSION: Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expressions in rats with DM.
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spelling pubmed-62073902018-11-29 Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus Xu, Jun Cao, Lijun Suo, Yuan Xu, Xiaoqin Sun, Hui Xu, Songao Zhu, Xiangyun Yu, Huijie Cao, Weizhong Int J Nanomedicine Original Research BACKGROUND: The study of the experiment was to display the therapeutic function of insulin-loaded chitosan (insulin/chitosan) on mesenteric microcirculation via down-regulating cyclooxygenase-2 (COX-2) and vascular cell adhesion molecule (VCAM-1) expressions in rats with diabetes mellitus (DM) as compared to free insulin. METHODS: Diabetic rats were administrated with 24 U/kg insulin or 120 U/kg insulin/chitosan compounds. The blood and mesenteriums were collected, blood glucose levels, arteriole velocity, arteriole diameter, venular diameter, and hemodiapedesis were measured, and COX-2, VCAM-1 expressions were measured in mesenteriums tissues. RESULTS: Both insulin and insulin/chitosan administration decreased blood glucose and improved the state of mesenteric microcirculation through down-regulating COX-2 and VCAM-1 expressions as compared to DM groups, while insulin/chitosan remarkably augmented this functions. CONCLUSION: Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expressions in rats with DM. Dove Medical Press 2018-10-25 /pmc/articles/PMC6207390/ /pubmed/30498345 http://dx.doi.org/10.2147/IJN.S174030 Text en © 2018 Xu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Xu, Jun
Cao, Lijun
Suo, Yuan
Xu, Xiaoqin
Sun, Hui
Xu, Songao
Zhu, Xiangyun
Yu, Huijie
Cao, Weizhong
Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title_full Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title_fullStr Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title_full_unstemmed Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title_short Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title_sort chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating cox-2 and vcam-1 expression in rats with diabetes mellitus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207390/
https://www.ncbi.nlm.nih.gov/pubmed/30498345
http://dx.doi.org/10.2147/IJN.S174030
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