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Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

Bacterial factors favoring the unprecedented multidrug-resistant tuberculosis (MDR-TB) epidemic in the former Soviet Union remain unclear. We utilized whole genome sequencing and Bayesian statistics to analyze the evolutionary history, temporal emergence of resistance and transmission networks of MD...

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Autores principales: Merker, Matthias, Barbier, Maxime, Cox, Helen, Rasigade, Jean-Philippe, Feuerriegel, Silke, Kohl, Thomas Andreas, Diel, Roland, Borrell, Sonia, Gagneux, Sebastien, Nikolayevskyy, Vladyslav, Andres, Sönke, Nübel, Ulrich, Supply, Philip, Wirth, Thierry, Niemann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207422/
https://www.ncbi.nlm.nih.gov/pubmed/30373719
http://dx.doi.org/10.7554/eLife.38200
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author Merker, Matthias
Barbier, Maxime
Cox, Helen
Rasigade, Jean-Philippe
Feuerriegel, Silke
Kohl, Thomas Andreas
Diel, Roland
Borrell, Sonia
Gagneux, Sebastien
Nikolayevskyy, Vladyslav
Andres, Sönke
Nübel, Ulrich
Supply, Philip
Wirth, Thierry
Niemann, Stefan
author_facet Merker, Matthias
Barbier, Maxime
Cox, Helen
Rasigade, Jean-Philippe
Feuerriegel, Silke
Kohl, Thomas Andreas
Diel, Roland
Borrell, Sonia
Gagneux, Sebastien
Nikolayevskyy, Vladyslav
Andres, Sönke
Nübel, Ulrich
Supply, Philip
Wirth, Thierry
Niemann, Stefan
author_sort Merker, Matthias
collection PubMed
description Bacterial factors favoring the unprecedented multidrug-resistant tuberculosis (MDR-TB) epidemic in the former Soviet Union remain unclear. We utilized whole genome sequencing and Bayesian statistics to analyze the evolutionary history, temporal emergence of resistance and transmission networks of MDR Mycobacterium tuberculosis complex isolates from Karakalpakstan, Uzbekistan (2001–2006). One clade (termed Central Asian outbreak, CAO) dating back to 1974 (95% HPD 1969–1982) subsequently acquired resistance mediating mutations to eight anti-TB drugs. Introduction of standardized WHO-endorsed directly observed treatment, short-course in Karakalpakstan in 1998 likely selected for CAO-strains, comprising 75% of sampled MDR-TB isolates in 2005/2006. CAO-isolates were also identified in a published cohort from Russia (2008–2010). Similarly, the presence of mutations supposed to compensate bacterial fitness deficits was associated with transmission success and higher drug resistance rates. The genetic make-up of these MDR-strains threatens the success of both empirical and standardized MDR-TB therapies, including the newly WHO-endorsed short MDR-TB regimen in Uzbekistan.
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spelling pubmed-62074222018-11-05 Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia Merker, Matthias Barbier, Maxime Cox, Helen Rasigade, Jean-Philippe Feuerriegel, Silke Kohl, Thomas Andreas Diel, Roland Borrell, Sonia Gagneux, Sebastien Nikolayevskyy, Vladyslav Andres, Sönke Nübel, Ulrich Supply, Philip Wirth, Thierry Niemann, Stefan eLife Evolutionary Biology Bacterial factors favoring the unprecedented multidrug-resistant tuberculosis (MDR-TB) epidemic in the former Soviet Union remain unclear. We utilized whole genome sequencing and Bayesian statistics to analyze the evolutionary history, temporal emergence of resistance and transmission networks of MDR Mycobacterium tuberculosis complex isolates from Karakalpakstan, Uzbekistan (2001–2006). One clade (termed Central Asian outbreak, CAO) dating back to 1974 (95% HPD 1969–1982) subsequently acquired resistance mediating mutations to eight anti-TB drugs. Introduction of standardized WHO-endorsed directly observed treatment, short-course in Karakalpakstan in 1998 likely selected for CAO-strains, comprising 75% of sampled MDR-TB isolates in 2005/2006. CAO-isolates were also identified in a published cohort from Russia (2008–2010). Similarly, the presence of mutations supposed to compensate bacterial fitness deficits was associated with transmission success and higher drug resistance rates. The genetic make-up of these MDR-strains threatens the success of both empirical and standardized MDR-TB therapies, including the newly WHO-endorsed short MDR-TB regimen in Uzbekistan. eLife Sciences Publications, Ltd 2018-10-30 /pmc/articles/PMC6207422/ /pubmed/30373719 http://dx.doi.org/10.7554/eLife.38200 Text en © 2018, Merker et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Evolutionary Biology
Merker, Matthias
Barbier, Maxime
Cox, Helen
Rasigade, Jean-Philippe
Feuerriegel, Silke
Kohl, Thomas Andreas
Diel, Roland
Borrell, Sonia
Gagneux, Sebastien
Nikolayevskyy, Vladyslav
Andres, Sönke
Nübel, Ulrich
Supply, Philip
Wirth, Thierry
Niemann, Stefan
Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia
title Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia
title_full Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia
title_fullStr Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia
title_full_unstemmed Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia
title_short Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia
title_sort compensatory evolution drives multidrug-resistant tuberculosis in central asia
topic Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207422/
https://www.ncbi.nlm.nih.gov/pubmed/30373719
http://dx.doi.org/10.7554/eLife.38200
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