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Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog

A large abdominal mass was found in a dog. Histopathologically, the surface of the mass was covered with compressed adrenal gland tissue. The neoplastic cells showed typical features of malignant peripheral nerve sheath tumor (MPNST), including Antoni type A and type B pattern, and nuclear palisadin...

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Detalles Bibliográficos
Autores principales: ICHIKAWA, Mika, SUZUKI, Satoshi, TEI, Meina, NIBE, Kazumi, UCHIDA, Kazuyuki, ONO, Kenichiro, HIRAO, Hidehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207514/
https://www.ncbi.nlm.nih.gov/pubmed/30175755
http://dx.doi.org/10.1292/jvms.18-0431
Descripción
Sumario:A large abdominal mass was found in a dog. Histopathologically, the surface of the mass was covered with compressed adrenal gland tissue. The neoplastic cells showed typical features of malignant peripheral nerve sheath tumor (MPNST), including Antoni type A and type B pattern, and nuclear palisading. Immunohistochemically, these cells were positive for S100 protein, nerve growth factor receptor, nestin and claudin-1. The dog was euthanized because of the developing multiple metastatic lesions. The metastatic cells showed quite similar histopathological and immunohistochemical features as those in the original tumor. Although MPNST can develop at many body sites, this is the first report of MPNST originating from the adrenal gland in a dog.