Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog

A large abdominal mass was found in a dog. Histopathologically, the surface of the mass was covered with compressed adrenal gland tissue. The neoplastic cells showed typical features of malignant peripheral nerve sheath tumor (MPNST), including Antoni type A and type B pattern, and nuclear palisadin...

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Autores principales: ICHIKAWA, Mika, SUZUKI, Satoshi, TEI, Meina, NIBE, Kazumi, UCHIDA, Kazuyuki, ONO, Kenichiro, HIRAO, Hidehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207514/
https://www.ncbi.nlm.nih.gov/pubmed/30175755
http://dx.doi.org/10.1292/jvms.18-0431
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author ICHIKAWA, Mika
SUZUKI, Satoshi
TEI, Meina
NIBE, Kazumi
UCHIDA, Kazuyuki
ONO, Kenichiro
HIRAO, Hidehiro
author_facet ICHIKAWA, Mika
SUZUKI, Satoshi
TEI, Meina
NIBE, Kazumi
UCHIDA, Kazuyuki
ONO, Kenichiro
HIRAO, Hidehiro
author_sort ICHIKAWA, Mika
collection PubMed
description A large abdominal mass was found in a dog. Histopathologically, the surface of the mass was covered with compressed adrenal gland tissue. The neoplastic cells showed typical features of malignant peripheral nerve sheath tumor (MPNST), including Antoni type A and type B pattern, and nuclear palisading. Immunohistochemically, these cells were positive for S100 protein, nerve growth factor receptor, nestin and claudin-1. The dog was euthanized because of the developing multiple metastatic lesions. The metastatic cells showed quite similar histopathological and immunohistochemical features as those in the original tumor. Although MPNST can develop at many body sites, this is the first report of MPNST originating from the adrenal gland in a dog.
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spelling pubmed-62075142018-11-02 Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog ICHIKAWA, Mika SUZUKI, Satoshi TEI, Meina NIBE, Kazumi UCHIDA, Kazuyuki ONO, Kenichiro HIRAO, Hidehiro J Vet Med Sci Pathology A large abdominal mass was found in a dog. Histopathologically, the surface of the mass was covered with compressed adrenal gland tissue. The neoplastic cells showed typical features of malignant peripheral nerve sheath tumor (MPNST), including Antoni type A and type B pattern, and nuclear palisading. Immunohistochemically, these cells were positive for S100 protein, nerve growth factor receptor, nestin and claudin-1. The dog was euthanized because of the developing multiple metastatic lesions. The metastatic cells showed quite similar histopathological and immunohistochemical features as those in the original tumor. Although MPNST can develop at many body sites, this is the first report of MPNST originating from the adrenal gland in a dog. The Japanese Society of Veterinary Science 2018-09-03 2018-10 /pmc/articles/PMC6207514/ /pubmed/30175755 http://dx.doi.org/10.1292/jvms.18-0431 Text en ©2018 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
ICHIKAWA, Mika
SUZUKI, Satoshi
TEI, Meina
NIBE, Kazumi
UCHIDA, Kazuyuki
ONO, Kenichiro
HIRAO, Hidehiro
Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog
title Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog
title_full Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog
title_fullStr Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog
title_full_unstemmed Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog
title_short Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog
title_sort malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207514/
https://www.ncbi.nlm.nih.gov/pubmed/30175755
http://dx.doi.org/10.1292/jvms.18-0431
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