IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment

IL-36 cytokines, a subgroup of IL-1 family, comprise IL-36α, IL-36β, and IL-36γ agonists, abundantly expressed in psoriatic skin, and IL-36RA and IL-38 antagonists. In psoriatic skin, IL-36 cytokines interfere with keratinocyte cornification programs and induce the release of antimicrobial peptides...

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Detalles Bibliográficos
Autores principales: Mercurio, Laura, Morelli, Martina, Scarponi, Claudia, Eisenmesser, Elan Z., Doti, Nunzianna, Pagnanelli, Gianluca, Gubinelli, Emanuela, Mazzanti, Cinzia, Cavani, Andrea, Ruvo, Menotti, Dinarello, Charles A., Albanesi, Cristina, Madonna, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207563/
https://www.ncbi.nlm.nih.gov/pubmed/30377293
http://dx.doi.org/10.1038/s41419-018-1143-3

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