Emerging Roles of Fibroblast Growth Factor 10 in Cancer

Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with paracrine Fibroblast Growth Factor 10 (FGF10) has been implicated in multiple cance...

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Detalles Bibliográficos
Autores principales: Clayton, Natasha S., Grose, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207577/
https://www.ncbi.nlm.nih.gov/pubmed/30405704
http://dx.doi.org/10.3389/fgene.2018.00499
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author Clayton, Natasha S.
Grose, Richard P.
author_facet Clayton, Natasha S.
Grose, Richard P.
author_sort Clayton, Natasha S.
collection PubMed
description Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with paracrine Fibroblast Growth Factor 10 (FGF10) has been implicated in multiple cancers, including breast, prostate and pancreatic ductal adenocarcinoma. Here, we examine the mechanisms underlying FGF10-induced tumourigenesis and explore novel approaches to target FGF10 signaling in cancer.
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spelling pubmed-62075772018-11-07 Emerging Roles of Fibroblast Growth Factor 10 in Cancer Clayton, Natasha S. Grose, Richard P. Front Genet Genetics Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with paracrine Fibroblast Growth Factor 10 (FGF10) has been implicated in multiple cancers, including breast, prostate and pancreatic ductal adenocarcinoma. Here, we examine the mechanisms underlying FGF10-induced tumourigenesis and explore novel approaches to target FGF10 signaling in cancer. Frontiers Media S.A. 2018-10-24 /pmc/articles/PMC6207577/ /pubmed/30405704 http://dx.doi.org/10.3389/fgene.2018.00499 Text en Copyright © 2018 Clayton and Grose. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Clayton, Natasha S.
Grose, Richard P.
Emerging Roles of Fibroblast Growth Factor 10 in Cancer
title Emerging Roles of Fibroblast Growth Factor 10 in Cancer
title_full Emerging Roles of Fibroblast Growth Factor 10 in Cancer
title_fullStr Emerging Roles of Fibroblast Growth Factor 10 in Cancer
title_full_unstemmed Emerging Roles of Fibroblast Growth Factor 10 in Cancer
title_short Emerging Roles of Fibroblast Growth Factor 10 in Cancer
title_sort emerging roles of fibroblast growth factor 10 in cancer
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207577/
https://www.ncbi.nlm.nih.gov/pubmed/30405704
http://dx.doi.org/10.3389/fgene.2018.00499
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AT groserichardp emergingrolesoffibroblastgrowthfactor10incancer

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