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Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation

Autocrine activation of the complement receptors C3aR and CD46 by complement activation components C3a and C3b produced through C3 cleavage by the protease cathepsin L (CTSL) during T cell stimulation is a requirement for IFN-γ production and Th1 induction in human CD4(+) T cells. Thus, lack of auto...

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Detalles Bibliográficos
Autores principales:	Freeley, Simon, Cardone, John, Günther, Sira C., West, Erin E., Reinheckel, Thomas, Watts, Colin, Kemper, Claudia, Kolev, Martin V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207624/ https://www.ncbi.nlm.nih.gov/pubmed/30405635 http://dx.doi.org/10.3389/fimmu.2018.02449

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