Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease

The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expression networks that regulate the workings, and failings, o...

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Autores principales: Ackers-Johnson, Matthew, Tan, Wilson Lek Wen, Foo, Roger Sik-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207674/
https://www.ncbi.nlm.nih.gov/pubmed/30375391
http://dx.doi.org/10.1038/s41467-018-06894-8
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author Ackers-Johnson, Matthew
Tan, Wilson Lek Wen
Foo, Roger Sik-Yin
author_facet Ackers-Johnson, Matthew
Tan, Wilson Lek Wen
Foo, Roger Sik-Yin
author_sort Ackers-Johnson, Matthew
collection PubMed
description The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expression networks that regulate the workings, and failings, of the heart.
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spelling pubmed-62076742018-10-31 Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease Ackers-Johnson, Matthew Tan, Wilson Lek Wen Foo, Roger Sik-Yin Nat Commun Comment The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expression networks that regulate the workings, and failings, of the heart. Nature Publishing Group UK 2018-10-30 /pmc/articles/PMC6207674/ /pubmed/30375391 http://dx.doi.org/10.1038/s41467-018-06894-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Ackers-Johnson, Matthew
Tan, Wilson Lek Wen
Foo, Roger Sik-Yin
Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease
title Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease
title_full Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease
title_fullStr Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease
title_full_unstemmed Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease
title_short Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease
title_sort following hearts, one cell at a time: recent applications of single-cell rna sequencing to the understanding of heart disease
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207674/
https://www.ncbi.nlm.nih.gov/pubmed/30375391
http://dx.doi.org/10.1038/s41467-018-06894-8
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