Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

New Delhi metallo-β-lactamase-1 exhibits a broad substrate profile for hydrolysis of the penicillin, cephalosporin and ‘last resort’ carbapenems, and thus confers bacterial resistance to nearly all β-lactam antibiotics. Here we address whether the high catalytic efficiency for hydrolysis of these di...

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Detalles Bibliográficos
Autores principales: Sun, Zhizeng, Hu, Liya, Sankaran, Banumathi, Prasad, B. V. Venkataram, Palzkill, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207675/
https://www.ncbi.nlm.nih.gov/pubmed/30375382
http://dx.doi.org/10.1038/s41467-018-06839-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207675/
https://www.ncbi.nlm.nih.gov/pubmed/30375382
http://dx.doi.org/10.1038/s41467-018-06839-1

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