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Association between Neutrophil-to-Lymphocyte Ratio and Gut Microbiota in a Large Population: a Retrospective Cross-Sectional Study

Gut microbiota and blood neutrophil-to-lymphocyte ratio (NLR) are associated with systemic inflammation; however, data on the association between gut microbiota and NLR are lacking. We investigated the association between gut microbiota and NLR. A total of 1,309 subjects who had available data on NL...

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Autores principales: Yoon, Hee-Young, Kim, Han-Na, Lee, Su Hwan, Kim, Soo Jung, Chang, Yoosoo, Ryu, Seungho, Shin, Hocheol, Kim, Hyung-Lae, Lee, Jin Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207698/
https://www.ncbi.nlm.nih.gov/pubmed/30375452
http://dx.doi.org/10.1038/s41598-018-34398-4
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author Yoon, Hee-Young
Kim, Han-Na
Lee, Su Hwan
Kim, Soo Jung
Chang, Yoosoo
Ryu, Seungho
Shin, Hocheol
Kim, Hyung-Lae
Lee, Jin Hwa
author_facet Yoon, Hee-Young
Kim, Han-Na
Lee, Su Hwan
Kim, Soo Jung
Chang, Yoosoo
Ryu, Seungho
Shin, Hocheol
Kim, Hyung-Lae
Lee, Jin Hwa
author_sort Yoon, Hee-Young
collection PubMed
description Gut microbiota and blood neutrophil-to-lymphocyte ratio (NLR) are associated with systemic inflammation; however, data on the association between gut microbiota and NLR are lacking. We investigated the association between gut microbiota and NLR. A total of 1,309 subjects who had available data on NLR and 16 S rRNA sequencing of gut microbiota were included in this study. They were grouped according to NLR quartile (Q) as follows: lower Q (n = 328, <25% of NLR range), middle 2Q (n = 653, ≥25% to <75%) and upper Q (n = 328, ≥75%). The diversity and composition of the human gut microbiota in the groups were calculated. The phylogenetic diversity of gut microbiota in the lower group was significantly higher than in the middle 2Q group (P = 0.040). The beta-diversity was significantly different among the three groups (P = 0.043), between the lower and middle 2Q groups (P = 0.029), and between the lower and upper groups (P = 0.026). Bacteroides eggerthii showed a positive correlation with NLR (q = 0.015). The diversity and composition of the gut microbiome were different between the NLR groups. Particularly, patients with a lower NLR had a greater diversity of gut microbiota.
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spelling pubmed-62076982018-11-01 Association between Neutrophil-to-Lymphocyte Ratio and Gut Microbiota in a Large Population: a Retrospective Cross-Sectional Study Yoon, Hee-Young Kim, Han-Na Lee, Su Hwan Kim, Soo Jung Chang, Yoosoo Ryu, Seungho Shin, Hocheol Kim, Hyung-Lae Lee, Jin Hwa Sci Rep Article Gut microbiota and blood neutrophil-to-lymphocyte ratio (NLR) are associated with systemic inflammation; however, data on the association between gut microbiota and NLR are lacking. We investigated the association between gut microbiota and NLR. A total of 1,309 subjects who had available data on NLR and 16 S rRNA sequencing of gut microbiota were included in this study. They were grouped according to NLR quartile (Q) as follows: lower Q (n = 328, <25% of NLR range), middle 2Q (n = 653, ≥25% to <75%) and upper Q (n = 328, ≥75%). The diversity and composition of the human gut microbiota in the groups were calculated. The phylogenetic diversity of gut microbiota in the lower group was significantly higher than in the middle 2Q group (P = 0.040). The beta-diversity was significantly different among the three groups (P = 0.043), between the lower and middle 2Q groups (P = 0.029), and between the lower and upper groups (P = 0.026). Bacteroides eggerthii showed a positive correlation with NLR (q = 0.015). The diversity and composition of the gut microbiome were different between the NLR groups. Particularly, patients with a lower NLR had a greater diversity of gut microbiota. Nature Publishing Group UK 2018-10-30 /pmc/articles/PMC6207698/ /pubmed/30375452 http://dx.doi.org/10.1038/s41598-018-34398-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yoon, Hee-Young
Kim, Han-Na
Lee, Su Hwan
Kim, Soo Jung
Chang, Yoosoo
Ryu, Seungho
Shin, Hocheol
Kim, Hyung-Lae
Lee, Jin Hwa
Association between Neutrophil-to-Lymphocyte Ratio and Gut Microbiota in a Large Population: a Retrospective Cross-Sectional Study
title Association between Neutrophil-to-Lymphocyte Ratio and Gut Microbiota in a Large Population: a Retrospective Cross-Sectional Study
title_full Association between Neutrophil-to-Lymphocyte Ratio and Gut Microbiota in a Large Population: a Retrospective Cross-Sectional Study
title_fullStr Association between Neutrophil-to-Lymphocyte Ratio and Gut Microbiota in a Large Population: a Retrospective Cross-Sectional Study
title_full_unstemmed Association between Neutrophil-to-Lymphocyte Ratio and Gut Microbiota in a Large Population: a Retrospective Cross-Sectional Study
title_short Association between Neutrophil-to-Lymphocyte Ratio and Gut Microbiota in a Large Population: a Retrospective Cross-Sectional Study
title_sort association between neutrophil-to-lymphocyte ratio and gut microbiota in a large population: a retrospective cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207698/
https://www.ncbi.nlm.nih.gov/pubmed/30375452
http://dx.doi.org/10.1038/s41598-018-34398-4
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