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A perivascular niche for multipotent progenitors in the fetal testis
Androgens responsible for male sexual differentiation in utero are produced by Leydig cells in the fetal testicular interstitium. Leydig cells rarely proliferate and, hence, rely on constant differentiation of interstitial progenitors to increase their number during fetal development. The cellular o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207726/ https://www.ncbi.nlm.nih.gov/pubmed/30375389 http://dx.doi.org/10.1038/s41467-018-06996-3 |
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author | Kumar, Deepti L. DeFalco, Tony |
author_facet | Kumar, Deepti L. DeFalco, Tony |
author_sort | Kumar, Deepti L. |
collection | PubMed |
description | Androgens responsible for male sexual differentiation in utero are produced by Leydig cells in the fetal testicular interstitium. Leydig cells rarely proliferate and, hence, rely on constant differentiation of interstitial progenitors to increase their number during fetal development. The cellular origins of fetal Leydig progenitors and how they are maintained remain largely unknown. Here we show that Notch-active, Nestin-positive perivascular cells in the fetal testis are a multipotent progenitor population, giving rise to Leydig cells, pericytes, and smooth muscle cells. When vasculature is disrupted, perivascular progenitor cells fail to be maintained and excessive Leydig cell differentiation occurs, demonstrating that blood vessels are a critical component of the niche that maintains interstitial progenitor cells. Additionally, our data strongly supports a model in which fetal Leydig cell differentiation occurs by at least two different means, with each having unique progenitor origins and distinct requirements for Notch signaling to maintain the progenitor population. |
format | Online Article Text |
id | pubmed-6207726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62077262018-10-31 A perivascular niche for multipotent progenitors in the fetal testis Kumar, Deepti L. DeFalco, Tony Nat Commun Article Androgens responsible for male sexual differentiation in utero are produced by Leydig cells in the fetal testicular interstitium. Leydig cells rarely proliferate and, hence, rely on constant differentiation of interstitial progenitors to increase their number during fetal development. The cellular origins of fetal Leydig progenitors and how they are maintained remain largely unknown. Here we show that Notch-active, Nestin-positive perivascular cells in the fetal testis are a multipotent progenitor population, giving rise to Leydig cells, pericytes, and smooth muscle cells. When vasculature is disrupted, perivascular progenitor cells fail to be maintained and excessive Leydig cell differentiation occurs, demonstrating that blood vessels are a critical component of the niche that maintains interstitial progenitor cells. Additionally, our data strongly supports a model in which fetal Leydig cell differentiation occurs by at least two different means, with each having unique progenitor origins and distinct requirements for Notch signaling to maintain the progenitor population. Nature Publishing Group UK 2018-10-30 /pmc/articles/PMC6207726/ /pubmed/30375389 http://dx.doi.org/10.1038/s41467-018-06996-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kumar, Deepti L. DeFalco, Tony A perivascular niche for multipotent progenitors in the fetal testis |
title | A perivascular niche for multipotent progenitors in the fetal testis |
title_full | A perivascular niche for multipotent progenitors in the fetal testis |
title_fullStr | A perivascular niche for multipotent progenitors in the fetal testis |
title_full_unstemmed | A perivascular niche for multipotent progenitors in the fetal testis |
title_short | A perivascular niche for multipotent progenitors in the fetal testis |
title_sort | perivascular niche for multipotent progenitors in the fetal testis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207726/ https://www.ncbi.nlm.nih.gov/pubmed/30375389 http://dx.doi.org/10.1038/s41467-018-06996-3 |
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