SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2

Dysregulated ROR-γt-mediated IL-17 transcription is central to the pathogenesis of several inflammatory disorders, yet the molecular mechanisms that govern the transcription factor activity of ROR-γt in the regulation of IL-17 are not fully defined. Here we show that SUMO-conjugating enzyme Ubc9 int...

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Detalles Bibliográficos
Autores principales: Singh, Amir Kumar, Khare, Prashant, Obaid, Abeer, Conlon, Kevin P., Basrur, Venkatesha, DePinho, Ronald A., Venuprasad, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207785/
https://www.ncbi.nlm.nih.gov/pubmed/30375383
http://dx.doi.org/10.1038/s41467-018-06924-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207785/
https://www.ncbi.nlm.nih.gov/pubmed/30375383
http://dx.doi.org/10.1038/s41467-018-06924-5

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