A Rare Case of Pembrolizumab-Induced Reactivation of Hepatitis B

Hepatitis B virus (HBV) infection is common across the world, especially in Asia, Africa, Southern Europe, and Latin America. The association of HBV infection in patients suffering from different oncological conditions is well established. Many cases of HBV reactivation have been reported in patient...

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Autores principales: Pandey, Anita, Ezemenari, Susan, Liaukovich, Maksim, Richard, Ivan, Boris, Avezbakiyev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207901/
https://www.ncbi.nlm.nih.gov/pubmed/30416833
http://dx.doi.org/10.1155/2018/5985131
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author Pandey, Anita
Ezemenari, Susan
Liaukovich, Maksim
Richard, Ivan
Boris, Avezbakiyev
author_facet Pandey, Anita
Ezemenari, Susan
Liaukovich, Maksim
Richard, Ivan
Boris, Avezbakiyev
author_sort Pandey, Anita
collection PubMed
description Hepatitis B virus (HBV) infection is common across the world, especially in Asia, Africa, Southern Europe, and Latin America. The association of HBV infection in patients suffering from different oncological conditions is well established. Many cases of HBV reactivation have been reported in patients on immunosuppressive chemotherapy and in patients undergoing hematopoietic bone marrow transplantations. Only one case has been reported so far of HBV reactivation in a patient treated with programmed cell death receptor 1 (PD-1) checkpoint inhibitors in the setting of HIV status. We report a case of a 51-year-old male, former smoker, diagnosed with stage IV poorly differentiated adenocarcinoma of the lung, and started on pembrolizumab, who developed reactivation of chronic hepatitis requiring antiviral therapy.
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spelling pubmed-62079012018-11-11 A Rare Case of Pembrolizumab-Induced Reactivation of Hepatitis B Pandey, Anita Ezemenari, Susan Liaukovich, Maksim Richard, Ivan Boris, Avezbakiyev Case Rep Oncol Med Case Report Hepatitis B virus (HBV) infection is common across the world, especially in Asia, Africa, Southern Europe, and Latin America. The association of HBV infection in patients suffering from different oncological conditions is well established. Many cases of HBV reactivation have been reported in patients on immunosuppressive chemotherapy and in patients undergoing hematopoietic bone marrow transplantations. Only one case has been reported so far of HBV reactivation in a patient treated with programmed cell death receptor 1 (PD-1) checkpoint inhibitors in the setting of HIV status. We report a case of a 51-year-old male, former smoker, diagnosed with stage IV poorly differentiated adenocarcinoma of the lung, and started on pembrolizumab, who developed reactivation of chronic hepatitis requiring antiviral therapy. Hindawi 2018-10-17 /pmc/articles/PMC6207901/ /pubmed/30416833 http://dx.doi.org/10.1155/2018/5985131 Text en Copyright © 2018 Anita Pandey et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Pandey, Anita
Ezemenari, Susan
Liaukovich, Maksim
Richard, Ivan
Boris, Avezbakiyev
A Rare Case of Pembrolizumab-Induced Reactivation of Hepatitis B
title A Rare Case of Pembrolizumab-Induced Reactivation of Hepatitis B
title_full A Rare Case of Pembrolizumab-Induced Reactivation of Hepatitis B
title_fullStr A Rare Case of Pembrolizumab-Induced Reactivation of Hepatitis B
title_full_unstemmed A Rare Case of Pembrolizumab-Induced Reactivation of Hepatitis B
title_short A Rare Case of Pembrolizumab-Induced Reactivation of Hepatitis B
title_sort rare case of pembrolizumab-induced reactivation of hepatitis b
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207901/
https://www.ncbi.nlm.nih.gov/pubmed/30416833
http://dx.doi.org/10.1155/2018/5985131
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