Multimodal antidepressant vortioxetine causes analgesia in a mouse model of chronic neuropathic pain

Vortioxetine is a multimodal antidepressant that potently antagonizes 5-HT3 serotonin receptors, inhibits the high-affinity serotonin transporter, activates 5-HT1A and 5-HT1B receptors, and antagonizes 5-HT1D and 5-HT7 receptors. 5-HT3 receptors largely mediate the hyperalgesic activity of serotonin...

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Detalles Bibliográficos
Autores principales: Zuena, Anna Rita, Maftei, Daniela, Alemà, Giovanni Sebastiano, Dal Moro, Francesca, Lattanzi, Roberta, Casolini, Paola, Nicoletti, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207957/
https://www.ncbi.nlm.nih.gov/pubmed/30289053
http://dx.doi.org/10.1177/1744806918808987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207957/
https://www.ncbi.nlm.nih.gov/pubmed/30289053
http://dx.doi.org/10.1177/1744806918808987

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