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Auditory disorders and future therapies with delivery systems
Auditory function takes a major part in human life. While sensorineural hearing loss is related with many factors including genetic disorders, age and noise, the clear causes are not well understood. Even more, the currently available treatments with drugs cause side effects, which thus are consider...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207966/ https://www.ncbi.nlm.nih.gov/pubmed/30397431 http://dx.doi.org/10.1177/2041731418808455 |
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author | Lee, Jung-Hwan Lee, Min Young Lim, Yohan Knowles, Jonathan Kim, Hae-Won |
author_facet | Lee, Jung-Hwan Lee, Min Young Lim, Yohan Knowles, Jonathan Kim, Hae-Won |
author_sort | Lee, Jung-Hwan |
collection | PubMed |
description | Auditory function takes a major part in human life. While sensorineural hearing loss is related with many factors including genetic disorders, age and noise, the clear causes are not well understood. Even more, the currently available treatments with drugs cause side effects, which thus are considered suboptimal. Here, we communicate the delivery systems with biomaterials that can be possible therapeutic options to restore hearing and vestibular functions. We introduce briefly the various pathological factors related with hearing loss and the limitation of current therapies, detail the recent studies on delivery systems including nanoparticles and hydrogels and discuss future clinical availability. |
format | Online Article Text |
id | pubmed-6207966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-62079662018-11-05 Auditory disorders and future therapies with delivery systems Lee, Jung-Hwan Lee, Min Young Lim, Yohan Knowles, Jonathan Kim, Hae-Won J Tissue Eng Review Auditory function takes a major part in human life. While sensorineural hearing loss is related with many factors including genetic disorders, age and noise, the clear causes are not well understood. Even more, the currently available treatments with drugs cause side effects, which thus are considered suboptimal. Here, we communicate the delivery systems with biomaterials that can be possible therapeutic options to restore hearing and vestibular functions. We introduce briefly the various pathological factors related with hearing loss and the limitation of current therapies, detail the recent studies on delivery systems including nanoparticles and hydrogels and discuss future clinical availability. SAGE Publications 2018-10-30 /pmc/articles/PMC6207966/ /pubmed/30397431 http://dx.doi.org/10.1177/2041731418808455 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Lee, Jung-Hwan Lee, Min Young Lim, Yohan Knowles, Jonathan Kim, Hae-Won Auditory disorders and future therapies with delivery systems |
title | Auditory disorders and future therapies with delivery systems |
title_full | Auditory disorders and future therapies with delivery systems |
title_fullStr | Auditory disorders and future therapies with delivery systems |
title_full_unstemmed | Auditory disorders and future therapies with delivery systems |
title_short | Auditory disorders and future therapies with delivery systems |
title_sort | auditory disorders and future therapies with delivery systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207966/ https://www.ncbi.nlm.nih.gov/pubmed/30397431 http://dx.doi.org/10.1177/2041731418808455 |
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