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Auditory disorders and future therapies with delivery systems

Auditory function takes a major part in human life. While sensorineural hearing loss is related with many factors including genetic disorders, age and noise, the clear causes are not well understood. Even more, the currently available treatments with drugs cause side effects, which thus are consider...

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Autores principales: Lee, Jung-Hwan, Lee, Min Young, Lim, Yohan, Knowles, Jonathan, Kim, Hae-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207966/
https://www.ncbi.nlm.nih.gov/pubmed/30397431
http://dx.doi.org/10.1177/2041731418808455
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author Lee, Jung-Hwan
Lee, Min Young
Lim, Yohan
Knowles, Jonathan
Kim, Hae-Won
author_facet Lee, Jung-Hwan
Lee, Min Young
Lim, Yohan
Knowles, Jonathan
Kim, Hae-Won
author_sort Lee, Jung-Hwan
collection PubMed
description Auditory function takes a major part in human life. While sensorineural hearing loss is related with many factors including genetic disorders, age and noise, the clear causes are not well understood. Even more, the currently available treatments with drugs cause side effects, which thus are considered suboptimal. Here, we communicate the delivery systems with biomaterials that can be possible therapeutic options to restore hearing and vestibular functions. We introduce briefly the various pathological factors related with hearing loss and the limitation of current therapies, detail the recent studies on delivery systems including nanoparticles and hydrogels and discuss future clinical availability.
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spelling pubmed-62079662018-11-05 Auditory disorders and future therapies with delivery systems Lee, Jung-Hwan Lee, Min Young Lim, Yohan Knowles, Jonathan Kim, Hae-Won J Tissue Eng Review Auditory function takes a major part in human life. While sensorineural hearing loss is related with many factors including genetic disorders, age and noise, the clear causes are not well understood. Even more, the currently available treatments with drugs cause side effects, which thus are considered suboptimal. Here, we communicate the delivery systems with biomaterials that can be possible therapeutic options to restore hearing and vestibular functions. We introduce briefly the various pathological factors related with hearing loss and the limitation of current therapies, detail the recent studies on delivery systems including nanoparticles and hydrogels and discuss future clinical availability. SAGE Publications 2018-10-30 /pmc/articles/PMC6207966/ /pubmed/30397431 http://dx.doi.org/10.1177/2041731418808455 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Lee, Jung-Hwan
Lee, Min Young
Lim, Yohan
Knowles, Jonathan
Kim, Hae-Won
Auditory disorders and future therapies with delivery systems
title Auditory disorders and future therapies with delivery systems
title_full Auditory disorders and future therapies with delivery systems
title_fullStr Auditory disorders and future therapies with delivery systems
title_full_unstemmed Auditory disorders and future therapies with delivery systems
title_short Auditory disorders and future therapies with delivery systems
title_sort auditory disorders and future therapies with delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207966/
https://www.ncbi.nlm.nih.gov/pubmed/30397431
http://dx.doi.org/10.1177/2041731418808455
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