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Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

The molecular chaperone Hsp90 is critical for the maintenance of cellular homeostasis and represents a promising drug target. Despite increasing knowledge on the structure of Hsp90, the molecular basis of substrate recognition and pro-folding by Hsp90/co-chaperone complexes remains unknown. Here, we...

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Detalles Bibliográficos
Autores principales:	Oroz, Javier, Chang, Bliss J., Wysoczanski, Piotr, Lee, Chung-Tien, Pérez-Lara, Ángel, Chakraborty, Pijush, Hofele, Romina V., Baker, Jeremy D., Blair, Laura J., Biernat, Jacek, Urlaub, Henning, Mandelkow, Eckhard, Dickey, Chad A., Zweckstetter, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208366/ https://www.ncbi.nlm.nih.gov/pubmed/30382094 http://dx.doi.org/10.1038/s41467-018-06880-0

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