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APE1 stimulates EGFR-TKI resistance by activating Akt signaling through a redox-dependent mechanism in lung adenocarcinoma

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have become the standard first-line treatment for advanced lung adenocarcinoma (LUAD) cancer patients with activating EGFR mutations. However, most patients show acquired resistance to EGFR-TKIs, thereby resulting in a modest ov...

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Detalles Bibliográficos
Autores principales:	Lu, Guo-Shou, Li, Mengxia, Xu, Cheng-Xiong, Wang, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208429/ https://www.ncbi.nlm.nih.gov/pubmed/30382076 http://dx.doi.org/10.1038/s41419-018-1162-0

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