Cargando…

Comparison of the effects of stellate ganglion block and paroxetine on hot flashes and sleep disturbance in breast cancer survivors

BACKGROUND: The incidence of menopausal symptoms, including hot flashes and sleep disturbance, caused by drug treatment is a common problem in breast cancer survivors. Considering the limitations of hormone therapy in such patients, several studies have been conducted to find alternative methods. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Rahimzadeh, Poupak, Imani, Farnad, Nafissi, Nahid, Ebrahimi, Behzad, Faiz, Seyed Hamid Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208490/
https://www.ncbi.nlm.nih.gov/pubmed/30464591
http://dx.doi.org/10.2147/CMAR.S173511
_version_ 1783366720477462528
author Rahimzadeh, Poupak
Imani, Farnad
Nafissi, Nahid
Ebrahimi, Behzad
Faiz, Seyed Hamid Reza
author_facet Rahimzadeh, Poupak
Imani, Farnad
Nafissi, Nahid
Ebrahimi, Behzad
Faiz, Seyed Hamid Reza
author_sort Rahimzadeh, Poupak
collection PubMed
description BACKGROUND: The incidence of menopausal symptoms, including hot flashes and sleep disturbance, caused by drug treatment is a common problem in breast cancer survivors. Considering the limitations of hormone therapy in such patients, several studies have been conducted to find alternative methods. The aim of this study was to investigate and compare the effectiveness of stellate ganglion block (SGB) with that of paroxetine, which was approved by the US Food and Drug Administration (FDA) as a medicine for the treatment of hot flashes and ensuing sleep disturbance. PATIENTS AND METHODS: A total of 40 patients survived from breast cancer and complaining of these symptoms were equally assigned to two groups of 20 each. In the study group, SGB was performed successfully under sonography guidance using 10 mL of 0.5% bupivacaine, and in the control group (paroxetine), the daily administration of 7.5 mg of paroxetine was conducted for 6 weeks. The frequency and severity of hot flash attacks and sleep quality of patients were evaluated prior to the intervention and after 2, 4 and 6 weeks. The incidence of adverse events during treatment or follow-up was recorded. RESULTS: A significant decrease in hot flash score and sleep disturbance index (SDI) was observed in both groups. Comparison of the results showed no noticeable difference between the two groups. Two participants in the control group had discontinued medication due to gastrointestinal symptoms, and only one case of mild headache was reported in the study group. CONCLUSION: SGB is as much effective as paroxetine in controlling hot flashes and sleep disturbances in breast cancer survivors and is associated with few complications.
format Online
Article
Text
id pubmed-6208490
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-62084902018-11-21 Comparison of the effects of stellate ganglion block and paroxetine on hot flashes and sleep disturbance in breast cancer survivors Rahimzadeh, Poupak Imani, Farnad Nafissi, Nahid Ebrahimi, Behzad Faiz, Seyed Hamid Reza Cancer Manag Res Original Research BACKGROUND: The incidence of menopausal symptoms, including hot flashes and sleep disturbance, caused by drug treatment is a common problem in breast cancer survivors. Considering the limitations of hormone therapy in such patients, several studies have been conducted to find alternative methods. The aim of this study was to investigate and compare the effectiveness of stellate ganglion block (SGB) with that of paroxetine, which was approved by the US Food and Drug Administration (FDA) as a medicine for the treatment of hot flashes and ensuing sleep disturbance. PATIENTS AND METHODS: A total of 40 patients survived from breast cancer and complaining of these symptoms were equally assigned to two groups of 20 each. In the study group, SGB was performed successfully under sonography guidance using 10 mL of 0.5% bupivacaine, and in the control group (paroxetine), the daily administration of 7.5 mg of paroxetine was conducted for 6 weeks. The frequency and severity of hot flash attacks and sleep quality of patients were evaluated prior to the intervention and after 2, 4 and 6 weeks. The incidence of adverse events during treatment or follow-up was recorded. RESULTS: A significant decrease in hot flash score and sleep disturbance index (SDI) was observed in both groups. Comparison of the results showed no noticeable difference between the two groups. Two participants in the control group had discontinued medication due to gastrointestinal symptoms, and only one case of mild headache was reported in the study group. CONCLUSION: SGB is as much effective as paroxetine in controlling hot flashes and sleep disturbances in breast cancer survivors and is associated with few complications. Dove Medical Press 2018-10-26 /pmc/articles/PMC6208490/ /pubmed/30464591 http://dx.doi.org/10.2147/CMAR.S173511 Text en © 2018 Rahimzadeh et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Rahimzadeh, Poupak
Imani, Farnad
Nafissi, Nahid
Ebrahimi, Behzad
Faiz, Seyed Hamid Reza
Comparison of the effects of stellate ganglion block and paroxetine on hot flashes and sleep disturbance in breast cancer survivors
title Comparison of the effects of stellate ganglion block and paroxetine on hot flashes and sleep disturbance in breast cancer survivors
title_full Comparison of the effects of stellate ganglion block and paroxetine on hot flashes and sleep disturbance in breast cancer survivors
title_fullStr Comparison of the effects of stellate ganglion block and paroxetine on hot flashes and sleep disturbance in breast cancer survivors
title_full_unstemmed Comparison of the effects of stellate ganglion block and paroxetine on hot flashes and sleep disturbance in breast cancer survivors
title_short Comparison of the effects of stellate ganglion block and paroxetine on hot flashes and sleep disturbance in breast cancer survivors
title_sort comparison of the effects of stellate ganglion block and paroxetine on hot flashes and sleep disturbance in breast cancer survivors
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208490/
https://www.ncbi.nlm.nih.gov/pubmed/30464591
http://dx.doi.org/10.2147/CMAR.S173511
work_keys_str_mv AT rahimzadehpoupak comparisonoftheeffectsofstellateganglionblockandparoxetineonhotflashesandsleepdisturbanceinbreastcancersurvivors
AT imanifarnad comparisonoftheeffectsofstellateganglionblockandparoxetineonhotflashesandsleepdisturbanceinbreastcancersurvivors
AT nafissinahid comparisonoftheeffectsofstellateganglionblockandparoxetineonhotflashesandsleepdisturbanceinbreastcancersurvivors
AT ebrahimibehzad comparisonoftheeffectsofstellateganglionblockandparoxetineonhotflashesandsleepdisturbanceinbreastcancersurvivors
AT faizseyedhamidreza comparisonoftheeffectsofstellateganglionblockandparoxetineonhotflashesandsleepdisturbanceinbreastcancersurvivors