Cargando…

Asiatic acid ameliorates CCl(4)-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways

PURPOSE: Currently, there are no effective therapies for liver fibrosis; hence, the development of anti-liver fibrosis agents is urgently needed. Here, we attempted to investigate the therapeutic effect and mechanism of asiatic acid (AA) on liver fibrosis, mainly focusing on the impact of AA on nucl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Jie, Chen, Qingshan, Wei, Liwen, Zhou, Xiaoming, Wang, Rong, Zhang, Hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208532/ https://www.ncbi.nlm.nih.gov/pubmed/30464391 http://dx.doi.org/10.2147/DDDT.S179876

Ejemplares similares

Tanshinol ameliorates CCl(4)-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway
por: Wang, Rong, et al.
Publicado: (2018)

Gentiopicroside ameliorates CCl(4)-induced liver injury in mice by regulating the PPAR-γ/Nrf2 and NF-κB/IκB signaling pathways
por: Zhang, Yun, et al.
Publicado: (2023)

Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-Regulation of JAK-STAT and NF-κB Signaling Pathways
por: Jia, Yan, et al.
Publicado: (2011)

Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways
por: Czerkies, Maciej, et al.
Publicado: (2018)

Xanthatin inhibits STAT3 and NF‐κB signalling by covalently binding to JAK and IKK kinases
por: Liu, Man, et al.
Publicado: (2019)

P990: NF-ΚB AND JAK/STAT PATHWAYS INHIBITION REVERSES FIBROSIS IN A MURINE MODEL OF INFLAMMATION-DRIVEN MYELOFIBROSIS
por: Zamora, Ernesto José Cuenca, et al.
Publicado: (2023)

Maslinic Acid Ameliorates Inflammation via the Downregulation of NF-κB and STAT-1
por: Lee, Wonhwa, et al.
Publicado: (2020)

TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-κB pathway
por: Huang, Ji-Cheng, et al.
Publicado: (2022)

Lirioresinol B dimethyl ether inhibits NF-κB and COX-2 and activates IκBα expression in CCl(4)-induced hepatic fibrosis
por: Shehzad, Adeeb, et al.
Publicado: (2020)

Amentoflavone Ameliorates Carrageenan-Induced Pleurisy and Lung Injury by Inhibiting the NF-κB/STAT3 Pathways via Nrf2 Activation
por: Hou, Tianhua, et al.
Publicado: (2022)

Cyanidin Alleviated CCl(4)-Induced Acute Liver Injury by Regulating the Nrf2 and NF-κB Signaling Pathways
por: Wang, Bulei, et al.
Publicado: (2022)

Mesoporous Silica Nanoparticles Trigger Liver and Kidney Injury and Fibrosis Via Altering TLR4/NF-κB, JAK2/STAT3 and Nrf2/HO-1 Signaling in Rats
por: Mahmoud, Ayman M., et al.
Publicado: (2019)

HLA-B*57:01/Carbamazepine-10,11-Epoxide Association Triggers Upregulation of the NFκB and JAK/STAT Pathways
por: Haukamp, Funmilola Josephine, et al.
Publicado: (2023)

Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice
por: Zhang, Peng, et al.
Publicado: (2023)

Loganin Inhibits Angiotensin II–Induced Cardiac Hypertrophy Through the JAK2/STAT3 and NF-κB Signaling Pathways
por: Xu, Jia-jia, et al.
Publicado: (2021)

Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways
por: Xu, Chang, et al.
Publicado: (2022)

Cigarette smoke-induced lung inflammation in COPD mediated via CCR1/JAK/STAT /NF-κB pathway
por: Zhao, Kaishun, et al.
Publicado: (2020)

JAK–STAT signalling shapes the NF‐κB response in CLL towards venetoclax sensitivity or resistance via Bcl‐XL
por: Haselager, Marco V., et al.
Publicado: (2023)

STAT3/NF-κB decoy oligodeoxynucleotides inhibit atherosclerosis through regulation of the STAT/NF-κB signaling pathway in a mouse model of atherosclerosis
por: An, Hyun-Jin, et al.
Publicado: (2023)

Therapeutic Targeting of GSK3β-Regulated Nrf2 and NFκB Signaling Pathways by Salvianolic Acid A Ameliorates Peritoneal Fibrosis
por: Zhou, Fan, et al.
Publicado: (2022)

Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation
por: Platanitis, Ekaterini, et al.
Publicado: (2018)

Kweichow Moutai ameliorates alcohol‐induced liver fibrosis in mice by targeting the NFκB pathway
por: Yang, Tao, et al.
Publicado: (2020)

Targeting the NF-κB pathway enhances responsiveness of mammary tumors to JAK inhibitors
por: Bapat, Aditi S., et al.
Publicado: (2023)

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
por: Bellezza, Ilaria, et al.
Publicado: (2010)

Systematic identifiability testing for unambiguous mechanistic modeling – application to JAK-STAT, MAP kinase, and NF-κB signaling pathway models
por: Quaiser, Tom, et al.
Publicado: (2009)

Curculigoside exerts significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway
por: Tan, Shirui, et al.
Publicado: (2019)

TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent
por: Liniger, Matthias, et al.
Publicado: (2021)

Scaffold compound L971 exhibits anti‐inflammatory activities through inhibition of JAK/STAT and NFκB signalling pathways
por: Li, Mengyuan, et al.
Publicado: (2021)

Bioactive compound C498-0670 alleviates LPS-induced sepsis via JAK/STAT and NFκB signaling pathways
por: Xu, Jing, et al.
Publicado: (2023)

Protective Effects of Taurine Chloramine on Experimentally Induced Colitis: NFκB, STAT3, and Nrf2 as Potential Targets
por: Kim, Seong Hoon, et al.
Publicado: (2021)

Chrysin Inhibits NF-κB-Dependent CCL5 Transcription by Targeting IκB Kinase in the Atopic Dermatitis-Like Inflammatory Microenvironment
por: Yeo, Hyunjin, et al.
Publicado: (2020)

Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling
por: Atwa, Ahmed M., et al.
Publicado: (2022)

Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation
por: Rodríguez, María José, et al.
Publicado: (2021)

Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF‐κB Signaling Pathway
por: Yuan, Shi‐guo, et al.
Publicado: (2022)

CCL3 Promotes Proliferation of Colorectal Cancer Related with TRAF6/NF-κB Molecular Pathway
por: Ma, Xiaoqiang, et al.
Publicado: (2022)

Protective Effects of Naringenin and Apigenin in Ameliorating Skin Damage via Mediating the Nrf2 and NF-κB Pathways in Mice
por: Li, Jie, et al.
Publicado: (2023)

Schisandrin B attenuates CCl(4)-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways
por: Chen, Qingshan, et al.
Publicado: (2017)

Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway
por: Han, Xue, et al.
Publicado: (2022)

NF-κB and Disease
por: Poma, Paola
Publicado: (2020)

Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways
por: Li, Rui, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5hg1ubtsat90lqvn9uf2ojod20