Cargando…

Progress in Inherited Retinal Disease Drug Discovery and Development: A Foundation’s Perspective

Ophthalmic drug discovery and development has enjoyed a recent renaissance, with a major shift away from reformulating old systemic drugs for ocular use to de novo discovery of drugs for specific ocular disease targets. This shift, coupled with a revolution in molecular biology and genetic sequencin...

Descripción completa

Detalles Bibliográficos
Autor principal:	Yerxa, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208581/ https://www.ncbi.nlm.nih.gov/pubmed/30338398 http://dx.doi.org/10.1007/s11095-018-2514-2

Ejemplares similares

Implementation of a registry and open access genetic testing program for inherited retinal diseases within a non‐profit foundation
por: Mansfield, Brian C., et al.
Publicado: (2020)

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations
por: MacDonald, Ian M., et al.
Publicado: (2020)

Drug Discovery Strategies for Inherited Retinal Degenerations
por: Das, Arupratan, et al.
Publicado: (2022)

Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps
por: Duncan, Jacque L., et al.
Publicado: (2018)

A perspective on multi-target drug discovery and design for complex diseases
por: Ramsay, Rona R., et al.
Publicado: (2018)

The Coming of Age of AI/ML in Drug Discovery, Development, Clinical Testing, and Manufacturing: The FDA Perspectives
por: Niazi, Sarfaraz K
Publicado: (2023)

Cellular reprogramming and inherited peripheral neuropathies: perspectives and challenges
por: Saporta, Mario A.
Publicado: (2015)

Open drug discovery in Alzheimer's disease
por: Axtman, Alison D., et al.
Publicado: (2023)

Versatile applications of deep eutectic solvents in drug discovery and drug delivery systems: Perspectives and opportunities
por: Hayyan, Maan
Publicado: (2023)

The potential of small molecule brain-derived neurotrophic factor: mimetics to treat inherited retinal degeneration
por: Cerquone Perpetuini, Andrea, et al.
Publicado: (2019)

Drug discovery and development: Role of basic biological research
por: Mohs, Richard C., et al.
Publicado: (2017)

Transgenerational epigenetic inheritance and social responsibility: perspectives from the social sciences
por: Meloni, Maurizio, et al.
Publicado: (2018)

Perspective: The promises of a holistic view of proteins—impact on antibody engineering and drug discovery
por: Phua, Ser-Xian, et al.
Publicado: (2019)

Perspective on model‐informed drug development
por: Lesko, Lawrence J.
Publicado: (2021)

WIPO Re:Search: Catalyzing Public-Private Partnerships to Accelerate Tropical Disease Drug Discovery and Development
por: Manner, Cathyryne K., et al.
Publicado: (2019)

Epigenetic Inheritance: Impact for Biology and Society—recent progress, current questions and future challenges
por: Arzate-Mejía, Rodrigo G, et al.
Publicado: (2022)

Paramagnetic NMR in drug discovery
por: Softley, Charlotte A., et al.
Publicado: (2020)

Foundations of complexity economics
por: Arthur, W. Brian
Publicado: (2021)

Has the Time Come for Predictive Computer Modeling in CNS Drug Discovery and Development?
por: Geerts, H, et al.
Publicado: (2012)

Tackling the Challenges of Product Development Through a Collaborative Rare Disease Network: The Foundation Fighting Blindness Consortium
por: Durham, Todd A., et al.
Publicado: (2021)

The pK(a) Distribution of Drugs: Application to Drug Discovery
por: Manallack, David T.
Publicado: (2007)

Common ground: The foundation of interdisciplinary research on bat disease emergence
por: Kading, Rebekah C., et al.
Publicado: (2020)

Evolutionary foundations for cancer biology
por: Aktipis, C Athena, et al.
Publicado: (2013)

The Foundation Fighting Blindness Plays an Essential and Expansive Role in Driving Genetic Research for Inherited Retinal Diseases
por: Shaberman, Ben, et al.
Publicado: (2019)

Editorial: Building on a Firm Foundation
por: Tilson, Hugh A.
Publicado: (2008)

Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery
por: Bennett, David A.
Publicado: (2017)

Pediatric GNAO1 encephalopathies: from molecular etiology of the disease to drug discovery
por: Katanaev, Vladimir L., et al.
Publicado: (2023)

Strategies to Address Challenges in Neuroscience Drug Discovery and Development
por: O’Donnell, Patricio, et al.
Publicado: (2019)

Inherited Retinal Diseases
por: Ben-Yosef, Tamar
Publicado: (2022)

The future of molecular dynamics simulations in drug discovery
por: Borhani, David W., et al.
Publicado: (2011)

NMR in target driven drug discovery: why not?
por: Keiffer, Sébastien, et al.
Publicado: (2020)

Evolving paradigms for natural-product drug discovery
por: Cordell, Geoffrey A
Publicado: (2022)

Computational drug discovery under RNA times
por: Bernetti, Mattia, et al.
Publicado: (2022)

Future Perspectives of Prime Editing for the Treatment of Inherited Retinal Diseases
por: Hansen, Silja, et al.
Publicado: (2023)

Developmental origins of epigenetic transgenerational inheritance
por: Hanson, Mark A., et al.
Publicado: (2016)

Epigenetic Inheritance and Transgenerational Environmental Justice
por: Korolenko, Alexandra A., et al.
Publicado: (2023)

A Perspective on Quantitative Systems Pharmacology Applications to Clinical Drug Development
por: Bai, Jane P. F., et al.
Publicado: (2020)

The Oxford Questions on the foundations of quantum physics
por: Briggs, G. A. D., et al.
Publicado: (2013)

Neural Foundations of Ayres Sensory Integration(®)
por: Lane, Shelly J., et al.
Publicado: (2019)

Retinal imaging in inherited retinal diseases
por: Georgiou, Michalis, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4vs4m83eumtl912puj8vp54r5r